1214752-76-7Relevant academic research and scientific papers
Developing NHC-Iridium Catalysts for the Highly Efficient Enantioselective Intramolecular Hydroamination Reaction
Gao, Pengchao,Sipos, Gellért,Foster, Daven,Dorta, Reto
, p. 6060 - 6064 (2017)
Chiral, cationic NHC-iridium complexes are introduced as catalysts for the intramolecular hydroamination reaction of unactivated aminoalkenes. The catalysts show high activity in the construction of pyrrolidines, which are accessed with excellent optical purity. Enantiomerically enriched piperidines and indolines are also produced, and various functional groups are tolerated with this LTM system. A reaction mechanism is proposed, and a major deactivation pathway of these catalysts is presented and discussed.
Design, scope and mechanism of highly active and selective chiral NHC-iridium catalysts for the intramolecular hydroamination of a variety of unactivated aminoalkenes
Foster, Daven,Gao, Pengchao,Zhang, Ziyun,Sipos, Gellért,Sobolev, Alexandre N.,Nealon, Gareth,Falivene, Laura,Cavallo, Luigi,Dorta, Reto
, p. 3751 - 3767 (2021/03/26)
Chiral, cationic NHC-iridium complexes are introduced as catalysts for the intramolecular hydroamination reaction of unactivated aminoalkenes. The catalysts show high activity in the construction of a range of 5- and 6-membered N-heterocycles, which are accessed in excellent optical purity, with various functional groups being tolerated with this system. A major deactivation pathway is presented and eliminated by using alternative reaction conditions. A detailed experimental and computational study on the reaction mechanism is performed providing valuable insights into the mode of action of the catalytic system and pointing to future modifications to be made for this catalytic platform.
Rhodium-catalyzed asymmetric intramolecular hydroamination of unactivated alkenes
Shen, Xiaoqiang,Buchwald, Stephen L.
supporting information; experimental part, p. 564 - 567 (2010/04/05)
(Figure Presented) One for the Rh(oad): The first rhodiumcatalyzed asymmetric intramolecular hydroamination of unactivated olefins was developed by using dialkylbiaryl phosphine ligands (see scheme; cod = 1,5-cyclooctadiene, Cy = cyclohexyl). A variety of 2-methylpyrrolidines have been synthesized with high enantioselectivities.
