121492-06-6

Basic information

• Product Name: N-Boc-N-methylethylenediamine
• Synonyms: BOC,ME-EDA;BOC-N-METHYLETHYLENEDIAMINE;BUTTPARK 90\06-19;(2-AMINO-ETHYL)-METHYL-CARBAMIC ACID TERT-BUTYL ESTER;1-BOC-1-METHYL-ETHYLENEDIAMINE;TERT-BUTYL N-(2-AMINOETHYL)-N-METHYLCARBAMATE;N-T-BUTYLOXYCARBONYL-N-METHYL-ETHYLENEDIAMINE;N-TERT-BUTYLOXYCARBONYL-N-METHYL-ETHYLENEDIAMINE
• CAS NO: 121492-06-6
• Molecular Formula: C₈H₁₈N₂O₂
• Molecular Weight: 174.24
• Product Categories: Small molecule;Bifunctional Linkers;Building Blocks;Chemical Biology;Chemical Synthesis;Linkers and Crosslinkers;Nitrogen Compounds;Organic Building Blocks;Protected Amines
• Mol File: 121492-06-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 248-251 °C (decomp)
• Boiling Point: 79°C/0.4mmHg(lit.)
• Flash Point: >100 °C
• Appearance: Clear colorless to pale yellow/Liquid
• Density: 0.975 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.0536mmHg at 25°C
• Refractive Index: n20/D 1.447
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 9.44±0.10(Predicted)
• BRN: 3588326
• CAS DataBase Reference: N-Boc-N-methylethylenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-N-methylethylenediamine(121492-06-6)
• EPA Substance Registry System: N-Boc-N-methylethylenediamine(121492-06-6)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 2734
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 121492-06-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 121492-06-6 differently. You can refer to the following data:
1. N-Boc-N-methylethylenediamine is a compound useful in organic synthesis and other chemical processes.
2. Mono-protected building block.

Chemical Properties

Liquid

InChI:InChI=1/C8H18N2O2/c1-8(2,3)12-7(11)10(4)6-5-9/h5-6,9H2,1-4H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 109-81-9 N-methyl-ethane-1,2-diamine 

Downstream Products

• 183444-93-1 ((S)-5-[2-(tert-Butoxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-pentyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 718619-71-7 4'-(2-amino-ethyl)-methyl-carbamic acid tert-butyl ester-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole 
• 1111235-03-0 C₁₆H₂₄ClN₅O₂ 
• 1095024-67-1 C₂₀H₂₇N₅O₃ 
• 1093798-73-2 C₁₇H₂₆N₆O₃ 
• 1083175-74-9 tert-butyl N-methyl-N-(2-{[4-(trifluoromethyl)phenyl]formamido}ethyl)carbamate 
• 1051929-82-8 tert-butyl 2-(3-(5-(furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzylamino)-ethyl(methyl)carbamate 
• 1062163-44-3 1-{4-[1-(1-Benzyl-piperidin-4-yl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenyl}-3-(2-methylamino-ethyl)-urea 
• 1042434-79-6 tert-butyl (2-(2-aminobenzamido)ethyl)(methyl)carbamate 
• 906004-05-5 5-(3-{[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-methyl}-4-fluoro-phenyl)-indazole-1-carboxylic acid tert-butyl ester 
• 895133-14-9 [2-(6-benzenesulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylamino)-ethyl]-methyl-carbamic acid tert-butyl ester 

Relevant articles and documents

Cyclization-Activated Prodrugs. Basic Carbamates of 4-Hydroxyanisole

A series of basic carbamates of 4-hydroxyanisole was prepared and evaluated as progenitors of this melanocytotoxic phenol.All of the carbamates were relatively stable at low pH but released 4-hydroxyanisole cleanly at pH 7.4 at rates that were structure dependent.A detailed study of the N-methyl-N-carbamate showed that generation of the parent phenol followed first-order kinetics with t1/2 = 36.3 min at pH 7.4, 37 deg C, and was accompanied by formation of N,N'-dimethylimidazolidinone.These basic carbamates are examples of cyclization-activated prodrugs in which generation of the active drug is not linked to enzymatic cleavage but rather depends solely upon a predictable, intramolecular cyclization-elimination reaction.