1215-99-2

Upstream product

• 54916-28-8 1-[4-(4-methoxyphenoxy)phenyl]ethanone 
• 39177-38-3 4-(4-acetoxy-phenoxy)-benzoic acid 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 123-31-9 hydroquinone 

Downstream Products

• 1189339-42-1 [4-(4-acetyl-phenoxy)-phenoxy]-acetic acid ethyl ester 
• 1189339-43-2 3-[4-(4-ethoxycarbonylmethoxy-phenoxy)-phenyl]-but-2-enoic acid ethyl ester 
• 1189339-32-9 C₃₂H₃₆O₉ 
• 1189339-31-8 succinic acid mono-[2-(4-{4-[1-(1,2,5-trioxa-spiro[5.5]undec-3-yl)-vinyl]-phenoxy}-phenoxy)-ethyl] ester 
• 1189339-30-7 succinic acid mono-[2-(4-{4-[1-(6,7,10-trioxa-spiro[4.5]dec-8-yl)-vinyl]-phenoxy}-phenoxy)-ethyl] ester 
• 1189339-29-4 C₂₈H₃₂O₆ 
• 1189339-28-3 2-(4-{4-[1-(1,2,5-trioxa-spiro[5.5]undec-3-yl)-vinyl]-phenoxy}-phenoxy)-ethanol 
• 1189339-27-2 2-(4-{4-[1-(6,7,10-trioxa-spiro[4.5]dec-8-yl)-vinyl]-phenoxy}-phenoxy)-ethanol 
• 1189339-44-3 3-{4-[4-(2-hydroxy-ethoxy)-phenoxy]-phenyl}-but-2-en-1-ol 

Relevant academic research and scientific papers

Synthesis of novel 1,2,4-trioxanes and antimalarial evaluation against multidrug-resistant Plasmodium yoelii nigeriensis

Malaria epidemics represent one of the life-threatening diseases to low-income lying countries which subsequently affect the economic and social condition of mankind. In continuation in the development of a novel series of 1,2,4-trioxanes 13a1-c1, 13a2-c2, and 13a3-c3 have been prepared and further converted into their hemisuccinate derivatives 14a1-c1, 14a2-c2, and 14a3-c3 respectively. All these new compounds were evaluated for their antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in mice by both oral and intramuscular (im) routes. Hydroxy-functionalized trioxane 13a1 showed 80% protection and its hemisuccinate derivative 14a1 showed 100% protection at a dose of 48 mg/kg × 4 days by both routes, which is twice active than artemisinin by oral route.

NOVEL HYDROXY FUNCTIONALIZED 1, 2, 4-TRIOXANES AS ANTIMALARIAL AGENTS AND A PROCESS FOR THE PREPARATION THEREOF

The present invention relates to novel hydroxy functionalized 1, 2, 4-trioxanes of general formula (7) useful as antimalarial agents. This invention also relates to a process for the preparation of novel hydroxy functionalized 1, 2, 4- trioxanes and their

BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION

The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: An example is

Cyclodienones. X. Reaction of Halo-cyclohexadien-1-ones with Phenols in the Presence of α-Picoline and Preparation of 4-Hydroxy- and 2-Hydroxyphenyl Aryl Ethers

Reaction of 4-halocyclohexadienones such as 4-bromo-(1a), 4-chloro-2,4,6-tri-t-butyl-(1b), 2,4-dichloro-4,6-di-t-butyl-2,5-cyclohexadien-1-one, and 2,4-dichloro-2,6-di-t-butyl-3,5-cyclohexadien-1-one with phenols in the presence of α-picoline was carried out under various conditions.The reaction of 1a and 1b with phenols afforded the corresponding 2-aryloxy-4,6-di-t-butyl phenols together with various by-products.The AlCl3 catalyzed trans-t-butylation of 2-aroxy-4,6-di-t-butyl-phenols, which were obtained by the above reaction, afforded the corresponding 2-hydroxyphenyl aryl ethers.The similar reaction of 4-aroxy-2,4,6-tri-t-butyl-2,5-cyclohexadien-1-ones also afforded the corresponding 4-hydroxyphenyl aryl ethers.