1215006-89-5Relevant articles and documents
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
Velcicky, Juraj,Feifel, Roland,Hawtin, Stuart,Heng, Richard,Huppertz, Christine,Koch, Guido,Kroemer, Markus,Moebitz, Henrik,Revesz, Laszlo,Scheufler, Clemens,Schlapbach, Achim
scheme or table, p. 1293 - 1297 (2010/06/15)
New, selective 3-aminopyrazole based MK2-inhibitors were discovered by scaffold hopping strategy. The new derivatives proved to inhibit intracellular phosphorylation of hsp27 as well as LPS-induced TNFα release in cells. In addition, selected derivative 1