1215035-82-7

Upstream product

• 1215035-73-6 C₃₃H₄₃NO₆SSi 
• 54984-43-9 (1S,4R)-camphor-10-thiol 
• 194089-91-3 tert-butyl (2S,4R)-4-hydroxy-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)-pyrrolidine-1-carboxylate 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 1215035-88-3 C₃₆H₅₁NO₆SSi 
• 1215035-76-9 (1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one 
• 1256257-76-7 (1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylthio}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol 
• 1215035-86-1 (1S)-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylsulfonyl}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one 
• 1256257-77-8 (1S)-1-[{{(2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl}methylsulfonyl}methyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol 

Relevant academic research and scientific papers

ORGANOCATALYST

The present invention provides an organocatalyst of formula (I), wherein R1 is —H, —OH, —O—Si(R4)(R5)(R6) or C1-6alkoxy, in which R4, R5 and R6 are identical or differ

Remarkable reaction rate and excellent enantioselective direct α-amination of aldehydes with azodicarboxylates catalyzed by pyrrolidinylcamphor-derived organocatalysts

Remarkable reaction rate and excellent enantioselective direct α-amination of unmodified aldehydes with various azodicarboxylates was catalyzed by pyrrolidinylcamphor organocatalyst 2a (5 mol-%) to provide the desired aminated products with excellent chemical yields and high to excellent levels of enantioselectivity (up to >99%ee) at 0 °C in CH 2Cl2.

Pyrrolidinyl-camphor derivatives as a new class of organocatalyst for direct asymmetric Michael addition of aldehydes and ketones to β-nitroalkenes

Practical and convenient synthetic routes have been developed for the synthesis of a new class of pyrrolidinyl-camphor derivatives (7a-h). These novel compounds were screened as catalysts for the direct Michael addition of symmetrical αα-disubstituted ald