1215067-70-1

Basic information

• Product Name: C₁₉H₂₅NO₄
• Synonyms: C₁₉H₂₅NO₄
• CAS NO: 1215067-70-1
• Molecular Weight: 331.412
• Mol File: 1215067-70-1.mol

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₅NO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₅NO₄(1215067-70-1)
• EPA Substance Registry System: C₁₉H₂₅NO₄(1215067-70-1)

Safety Data

• Hazardous Substances Data: 1215067-70-1(Hazardous Substances Data)

Upstream product

• 930-68-7 cyclohexenone 
• 26782-71-8 D-tert-leucine 
• 1162662-41-0 (S)-2-((pyrrolidin-2-ylmethyl)thio)pyridine 
• 90-02-8 salicylaldehyde 

Relevant articles and documents

Dual organocatalytic ion-pair assemblies: A highly efficient approach for the enantioselective oxa-michael-mannich reaction of salicylic aldehydes with cyclohexenones

A study was conducted to demonstrate a novel type of bifunctional catalyst generated by the self-assembly of pyrrolidines and readily available primary amino acids. It was demonstrated that the protonation of the aromatic nitrogen atom of pyrrolidines by amino acids spontaneously led to ion-pair assemblies. The self-assembled catalysts possessed dual activation centers and enabled the catalysis of the electrophilic and nucleophilic substrates similar to catalysis by enzymes. The simultaneous activation of cyclohex-2-enone and salicylic aldehyde by pyrrolidines and amino acids generated the transient ion pairs through iminiums and imines. The resultant assemblies ensured that the enantioselective domino oxa-Michael addition and intramolecular Mannich reaction proceeded to afford the corresponding products upon hydrolysis.