121507-72-0

Basic information

• Product Name: 2-(2-ethoxycarbonylethyl)-1-phenoxycarbonyl-1,2,5,6-tetrahydropyridine
• Synonyms: 2-(2-ethoxycarbonylethyl)-1-phenoxycarbonyl-1,2,5,6-tetrahydropyridine
• CAS NO: 121507-72-0
• Molecular Weight: 303.358
• Mol File: 121507-72-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(2-ethoxycarbonylethyl)-1-phenoxycarbonyl-1,2,5,6-tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-ethoxycarbonylethyl)-1-phenoxycarbonyl-1,2,5,6-tetrahydropyridine(121507-72-0)
• EPA Substance Registry System: 2-(2-ethoxycarbonylethyl)-1-phenoxycarbonyl-1,2,5,6-tetrahydropyridine(121507-72-0)

Safety Data

• Hazardous Substances Data: 121507-72-0(Hazardous Substances Data)

Upstream product

• 121507-67-3 4-hydroxy-1-phenoxycarbonyl-1,2,3,4-tetrahydropyridine 
• 121507-66-2 (+/-)-1-((phenyloxy)carbonyl)-1,2,3,4-tetrahydro-4-pyridone 
• 24681-60-5 1,2,3,4-tetrahydro-4-oxopyridine 
• 104089-16-9 2-ethoxycarbonyethylzinc iodide 
• 121507-68-4 4-methoxy-1-phenoxycarbonyl-1,2,3,4-tetrahydropyridine 
• 620-08-6 4-methoxypyridine 

Relevant articles and documents

REGIO- AND STEREOSELECTIVE ADDITION OF NUCLEOPHILES TO 1-PHENOXYCARBONYL-2,3-DIHYDROPYRIDINIUM SALTS

Several 2-alkyl-1-phenoxycarbonyl-Δ3-piperidines were prepared by the addition of alkylzinc iodides to dihydropyridinium salt (9).The treatment of 4-hydroxy-2-methyl-1-phenoxycarbonyl-1,2,3,4-tetrahydropyridine (12) with allyltrimethylsilane in the presence of a variety of Lewis acids was studied and found to give cis- and trans-2,6-dialkyl-Δ3-piperidines (14) and (15) in moderate to good yield.Among the Lewis acids studied, stannyl chloride gave the best yield with good stereoselectivity (84:16) favoring the cis-isomer (14).The analogous reaction of the 4-metho xy derivative (13) with organozinc reagents was examined and found to give the cis-isomers (17) as the major products.Using this metodology, the cis-piperidine alkaloid (+/-)-dihydropinidine, was prepared in six steps from 4-methoxypyridine.

THE ADDITION OF ALKYLZINC IODIDES TO 1-(PHENOXYCARBONYL)-2,3-DIHYDROPYRIDINIUM SALTS. A SYNTHESIS OF 2-ALKYL-Δ3-PIPERIDINES.

Several 2-alkyl-1-(phenoxycarbonyl)-Δ3-piperidines were prepared by the addition of alkylzinc iodides to 1-(phenoxycarbonyl)-2,3-dihydropyridinium salts.