1215107-61-1

Basic information

• Product Name: 1-(Pyrimidin-2-yl)cyclopropanamine hydrochloride
• Synonyms: 1-(Pyrimidin-2-yl)cyclopropanamine hydrochloride;1-(PYRIMIDIN-2-YL)CYCLOPROPAN-1-AMINE HCL
• CAS NO: 1215107-61-1
• Molecular Formula: C₇H₉N₃*ClH
• Molecular Weight: 171.6274
• Mol File: 1215107-61-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(Pyrimidin-2-yl)cyclopropanamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Pyrimidin-2-yl)cyclopropanamine hydrochloride(1215107-61-1)
• EPA Substance Registry System: 1-(Pyrimidin-2-yl)cyclopropanamine hydrochloride(1215107-61-1)

Safety Data

• Hazardous Substances Data: 1215107-61-1(Hazardous Substances Data)

Usage

General Description

1-(Pyrimidin-2-yl)cyclopropanamine hydrochloride is a chemical compound with the molecular formula C8H12ClN3. It is a cyclopropanamine derivative with a pyrimidine group attached to the cyclopropane ring. 1-(Pyrimidin-2-yl)cyclopropanamine hydrochloride is often used in pharmaceutical research as a precursor for the synthesis of various biologically active compounds. It has also shown potential as a therapeutic agent for the treatment of certain diseases. The hydrochloride salt form of 1-(Pyrimidin-2-yl)cyclopropanamine offers improved stability and solubility, making it more suitable for pharmaceutical applications. Overall, this compound has various potential uses in the pharmaceutical industry and as a research tool for understanding the biological activity of related compounds.

Upstream product

• 1159734-40-3 (1-pyrimidin-2-ylcyclopropyl)carbamic acid tert-butyl ester 
• 1422356-97-5 benzyl (1-(5-chloropyrimidin-2-yl)cyclopropyl)carbamate 

Downstream Products

• 1159734-40-3 (1-pyrimidin-2-ylcyclopropyl)carbamic acid tert-butyl ester 
• 1353895-73-4 4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-(4-methoxy-2-methyl-5-(1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl-N-methylbenzofuran-3-carboxamide 
• 1332519-00-2 2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)-N-methylpyrazolo[1,5-b]pyridazine-3-carboxamide 
• 1215105-51-3 2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxamide 
• 1449332-97-1 5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxy-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide 

Relevant articles and documents

Development of a Scalable Route for a Highly Polar Heterocyclic Aminocyclopropyl Building Block

A robust and scalable route toward key heterocyclic building block 1-(pyrimidin-2-yl)cyclopropan-1-amine hydrochloride from cyclopropanated starting material 1-amino-1-cyclopropanecarbonitrile hydrochloride was successfully developed. The key to success was the construction of a pyrimidine ring via cyclization from an amidine intermediate and a bench-stable 2-chloro vinamidinium hexafluorophosphate salt. The cyclization was performed under mild conditions, and the resulting 4-cloropyrimidine derivative was isolated in high yield and purity. The final hydrogenation was intensively optimized: A combination of Pd(OH)2/C as a catalyst and NaOMe as a base at 1 bar H2 pressure in MeOH simultaneously cleaved the Cbz group and dechlorinated the pyrimidine ring while at the same time suppressing the over-reduction of the pyrimidine ring to below 1.0%. After acidification with HCl, followed by removal of the catalyst and NaCl by filtration, the final product was isolated in high yield and purity as a bench-stable off-white solid. The overall yield of the five-step sequence was 57%.