1215114-52-5

Basic information

• Product Name: 2-(4-bromo-1,3-diphenyl-1H-pyrazol-5-yl)-3-(4-methoxyphenyl)-3-(methylthio)-2-propenenitrile
• Synonyms: 2-(4-bromo-1,3-diphenyl-1H-pyrazol-5-yl)-3-(4-methoxyphenyl)-3-(methylthio)-2-propenenitrile
• CAS NO: 1215114-52-5
• Molecular Weight: 502.434
• Mol File: 1215114-52-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-bromo-1,3-diphenyl-1H-pyrazol-5-yl)-3-(4-methoxyphenyl)-3-(methylthio)-2-propenenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromo-1,3-diphenyl-1H-pyrazol-5-yl)-3-(4-methoxyphenyl)-3-(methylthio)-2-propenenitrile(1215114-52-5)
• EPA Substance Registry System: 2-(4-bromo-1,3-diphenyl-1H-pyrazol-5-yl)-3-(4-methoxyphenyl)-3-(methylthio)-2-propenenitrile(1215114-52-5)

Safety Data

• Hazardous Substances Data: 1215114-52-5(Hazardous Substances Data)

Upstream product

• 2168-77-6 p-(methoxy)dithiobenzoic acid 
• 74-88-4 methyl iodide 
• 1215114-73-0 2-(4-bromo-1,3-diphenyl-1H-pyrazol-5-yl)acetonitrile 
• 5874-09-9 methyl (4-methoxyphenyl)carbodithioate 

Downstream Products

• 1323859-42-2 1,3-diphenyl-5-(4-methoxyphenyl)-1H-thieno[3,2-c]pyrazole-6-carbonitrile 
• 1215114-66-1 8-methoxy-5-methylthio-1,3-diphenyl-3H-benzo[e]indazole-4-carbonitrile 

Relevant articles and documents

Synthesis of N-functionalized/NH-multisubstituted indoles, thienopyrroles, pyrroloindoles, and pyrazolopyrroles via sequential one-pot base-mediated and copper-catalyzed inter- and intramolecular amination of 2-[2-bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitriles

A novel, efficient route to substituted 1-N-(het)aryl/NH-2-(het)aryl-3-cyanoindoles and related pyrrolo-fused heterocycles such as thienopyrroles, pyrroloindoles, and pyrazolopyrroles has been reported. The overall protocol involves sequential cycloamination of readily available 2-[2-bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitrile precursors with primary amines or amides via two key C-N bond-forming processes, one base-mediated intermolecular and the other Cu-catalyzed intramolecular arylamination leading to N(1)-C(2) and N(1)-C(7a) bond formation, respectively, in a two-step one-pot procedure.