1215119-70-2Relevant academic research and scientific papers
Direct Asymmetric Three-Component Mannich Reaction Catalyzed by Chiral Counteranion-Assisted Silver
Borovkov, Victor,Guo, Jianxin,Hu, Xiaoyun,Yin, Zhongyou,Zhang, Rui
, p. 10369 - 10377 (2020)
Direct asymmetric three-component Mannich reaction involving simple ketones (such as cyclohexanone, acetone, and acetophenone) as donors and catalyzing by silver tartaric acid-derived phosphate was realized to afford a series of optically active β-amino-ketone derivatives in high yields (up to 96%) and good-to-high enantioselectivities (up to 97%) with moderate-to-good diastereoselectivities. This is the first example of direct catalytic asymmetric three-component Mannich reaction via a chiral counteranion-directed strategy.
Enzyme-catalyzed asymmetric Mannich reaction using acylase from Aspergillus melleus
Guan, Zhi,Song, Jian,Xue, Yang,Yang, Da-Cheng,He, Yan-Hong
, p. 16 - 20 (2015/01/30)
Acylase I from Aspergillus melleus (AMA) displayed catalytic promiscuity towards one-pot asymmetric Mannich reaction in acetonitrile for the first time. AMA showed favourable catalytic activity with good adaptability to different substrates. The activity
