121514-30-5

Basic information

• Product Name: 2-(3'-(5'-hydroxyindolyl)methyl)-1,3-thiazolidine-4-carboxylic acid
• Synonyms: 2-(3'-(5'-hydroxyindolyl)methyl)-1,3-thiazolidine-4-carboxylic acid
• CAS NO: 121514-30-5
• Molecular Formula: C13H14N2O3S
• Molecular Weight: 278.32686
• Mol File: 121514-30-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3'-(5'-hydroxyindolyl)methyl)-1,3-thiazolidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3'-(5'-hydroxyindolyl)methyl)-1,3-thiazolidine-4-carboxylic acid(121514-30-5)
• EPA Substance Registry System: 2-(3'-(5'-hydroxyindolyl)methyl)-1,3-thiazolidine-4-carboxylic acid(121514-30-5)

Safety Data

• Hazardous Substances Data: 121514-30-5(Hazardous Substances Data)

Upstream product

• 52-90-4 L-Cysteine 
• 153-98-0 serotonin hydrochloride 
• 1892-21-3 Hydroxyindoleacetaldehyde 

Relevant articles and documents

Metabolism of 5-Hydroxytryptamine by Brain Synaptosomes and Microsomes in the Presence of Cysteine and Glutathione

Incubation of 5-hydroxytryptamine (1) with L-cysteine and pig or bovine brain microsomes and an NADPH-generating system or with synaptosomes results in the rapid formation of the (2R,4R)- and (2S,4R)-epimers of 2-thiazolidine.Incubation of 1 and glutathione under the same experimental conditions yields the (2R,4R)- and (2S,4R)-epimers of α-amino-4-carbonyl>-2--?-oxo-3-thiazolidinepentanoic acid.These various thiazolidine derivatives are formed by nucleophilic addition of the thiol residues of cysteine or glutathione to the aldehyde group of 5-hydroxyindole-3-acetaldehyde (2), the primary product of the monoamine oxidase-mediated oxidative deamination of 1.The facile reaction of cysteine and glutathione with 2 might represent a mechanism designed to scavenge the biogenic aldehyde and therefore to prevent its alkylation of key intraneuronal protein nucleophiles.