1215168-37-8

Basic information

• Product Name: 2-Arachidonyl Glycerol-d5
• Synonyms: 2-Arachidonyl Glycerol-d5;(all-Z)-5,8,11,14-Eicosatetraenoic Acid 2-Hydroxy-1- (hydroxyMethyl)ethyl-d5 Ester;2-Monoarachidonoylglycerol-d5;5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic Acid 2-Hydroxy-1-(hydroxyMethyl) ethyl-d5 Ester
• CAS NO: 1215168-37-8
• Molecular Formula: C23H33D5O4
• Molecular Weight: 370
• Product Categories: Fatty Acid Derivatives & Lipids;Glycerols;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals;Glycerols, Fatty Acid Derivatives & Lipids, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1215168-37-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Arachidonyl Glycerol-d5(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Arachidonyl Glycerol-d5(1215168-37-8)
• EPA Substance Registry System: 2-Arachidonyl Glycerol-d5(1215168-37-8)

Safety Data

• Hazardous Substances Data: 1215168-37-8(Hazardous Substances Data)

Usage

Uses

Labelled 2-Arachidonoylglycerol (A765050). It is a major endocannabinoid, which can inhibit synaptic transmission by presynaptic cannabinoid CB1 receptors. It plays an inhibitory role in the bombesin-induced activation of central adrenomedullary outflow in rats.

Upstream product

• 62502-71-0 [1,1,2,3,3-2H₅]glycerol 
• 506-32-1 all cis 5,8,11,14-eicosatetraenoic acid 

Relevant articles and documents

Quantitative method for the profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS

The endocannabinoid system's biological significance continues to grow as novel endocannabinoid metabolites are discovered. Accordingly, a myopic view of the system that focuses solely on one or two endocannabinoids, such as anandamide or 2-arachidonoyl glycerol, is insufficient to describe the biological responses to perturbations of the system. Rather, the endocannabinoid metabolome as a whole must be analyzed. The work described here is based on liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometry. This method has been validated to quantify, in a single chromatographic run, the levels of 15 known or suspected metabolites of the endocannabinoid system in the rat brain and is applicable to other biological matrixes. We have obtained an endocannabinoid profile specifically for the frontal cortex of the rat brain and have determined anandamide level differences following the administration of the fatty acid amide hydrolase inhibitor AM374.