1215207-33-2Relevant academic research and scientific papers
Application of amide-stabilized sulfur ylide reactivity to the stereodivergent synthesis of (R,S)- and (S,R)-reboxetine
Aparicio, David M.,Teran, Joel L.,Gnecco, Dino,Galindo, Alberto,Juarez, Jorge R.,Orea, Maria L.,Mendoza, Angel
experimental part, p. 2764 - 2768 (2010/04/06)
A simple access to (R,S)- and (S,R)-reboxetine from a single chiral sulfonium salt 4 is reported. This approach, based on a stabilized sulfur ylide-mediated epoxidation, followed by a regioselective opening reaction, enables the preparation of these two p
