1215212-54-6Relevant academic research and scientific papers
Rapid assembly of gp120 oligosaccharide moieties via one-pot glycosidation-deprotection sequences
Pastore, Antonello,Adinolfi, Matteo,Iadonisi, Alfonso,Valerio, Silvia
experimental part, p. 1316 - 1323 (2010/10/02)
Mannosyl trihaloacetimidate donors equipped with a 2-O-Fmoc group can be effectively activated by catalytic Bi(OTf)3 in glycosidations. Despite the expected participating effect of the Fmoc group, the reaction solvent was found to be decisive f
One-pot catalytic glycosidation/Fmoc removal - An iterable sequence for straightforward assembly of oligosaccharides related to HIV gp120
Pastore, Antonello,Adinolfi, Matteo,Iadonisi, Alfonso,Valerio, Silvia
experimental part, p. 711 - 718 (2010/03/24)
The removal of a transient Fmoc protecting group can be simply performed by the addition of excess Et3N just after the accomplishment of a Bi(OTf)3-promoted glycosidation reaction. The obtained oligosaccharide can be directly employed as a glycosyl acceptor for further elongation of the saccharide. The preparation of biologically important, linear and branched mannans incorporated into HIV gp 120 demonstrates that the iteration of this one-pot sequence leads to a very straightforward oligosaccharide assembly.
