1215215-40-9Relevant academic research and scientific papers
Domino Grignard Addition and Oxidation for the One-Pot Synthesis of C2-Quaternary 2-Hydroxyindoxyls
Mandal, Tirtha,Chakraborti, Gargi,Maiti, Subhadip,Dash, Jyotirmayee
, p. 8044 - 8048 (2019)
We herein delineate an unexplored reactivity of 3-hydroxyoxindoles toward Grignard addition enabling a rapid access to a broad range of unnatural C2-quaternary 2-hydroxyindoxyls in high yields. The reaction proceeds via a mechanistically intriguing one-pot 1,2-hydride shift followed by autoxidation pathway. The utility of this method is demonstrated by the synthesis of a new class of bis-indoxyl spirofuran derivatives.
Preparation of 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones via oxidation of 2-substituted indoles and Mannich-type reaction
Higuchi, Kazuhiro,Sato, Yukihiro,Kojima, Shigeru,Tsuchimochi, Mei,Sugiura, Kenta,Hatori, Masatoshi,Kawasaki, Tomomi
experimental part, p. 1236 - 1243 (2010/03/30)
A novel preparative method for 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones through the oxidation of 2-arylindoles followed by a Mannich-type reaction with carbon nucleophiles is described.
