121524-18-3Relevant articles and documents
Preventives and remedies for ischemic intestinal lesion and ileus
-
, (2008/06/13)
The present invention relates to a prophylactic and/or therapeutic composition for ischemic intestinal lesions and/or ileus which comprises as an active ingredient a pyrazolopyridine compound of the following formula: [wherein R1is lower alkyl group, etc; R2is a group of the formula: (wherein R4is protected amino group, etc; R5is hydrogen, etc); etc, and R3is hydrogen, etc] or a salt thereof.
Discovery of FK453, a novel non-xanthine adenosine A1 receptor antagonist
Akahane, Atsushi,Katayama, Hirohito,Mitsunaga, Takafumi,Kita, Yasuhiro,Kusunoki, Takahiro,Terai, Takao,Yoshida, Keizo,Shiokawa, Youichi
, p. 2059 - 2062 (2007/10/03)
Novel 2-phenylpyrazolo[1,5-a]pyridine-3-acryloylamides were synthesized and evaluated for diuretic activities. FK453 (1d), the most potent compound in this series, was found to be a potent and selective adenosine A1 receptor antagonist, whereas 1e, the (S)-enantiomer of FK453, was a weak and non-selective adenosine antagonist.
Pharmaceutical method of treatment using pyrazolopyridine compound
-
, (2008/06/13)
The invention relates to a method for the treatment of ailments which comprises administering an effective amount of the pyrazolopyridine compounds of the invention.