1215288-69-9Relevant academic research and scientific papers
Aminobromination of β-nitrostyrene derivatives with N,N-dibromourethane as the aminobrominating reagent
Chen, Zhan-Guo,Zhao, Peng-Fei,Wang, Yun
experimental part, p. 5887 - 5893 (2011/11/06)
A concise and efficient aminobromination reaction for β-nitrostyrene derivatives by treatment with N,N-dibromourethane was developed. For the β-nitrostyrene derivatives, the aminobromination successfully proceeded at room temperature in CH3CN without catalysis or protection by an inert gas and gave products in excellent yields (80-97%). For the β-methyl analogs, the reaction proceeded smoothly with anhydrous K2CO 3 as a catalyst under the same conditions to provide the aminobrominated products in good yields (53-78%). A possible pathway for this electrophilic addition reaction is proposed.
K3PO4-catalyzed regiospecific aminobromination of βnitrostyrene derivatives with N-Bromoacetamide as aminobtominating agent
Chen, Zhan-Guo,Wang, Yun,Wei, Jun-Fa,Zhao, Peng-Fei,Shi, Xian-Ying
supporting information; experimental part, p. 2085 - 2088 (2010/06/16)
"Chemical Equation Presented" A very simple, efficient, and regiospecific protocol for aminobromination of a wide scope of β-nitrostyrene derivatives with N-bromoacetamide (NBA) as nitrogen/ bromine sources has been developed by using K3PO4 as catalyst. The reaction proceeded smoothly and cleanly to give the bromoamines in good to excellent yields (78-99%) within 24 h in CH2Cl2 at room temperature without protection of inert gases. A possible mechanism involving a nucleophilic conjugate addition was proposed.
