1215305-50-2Relevant academic research and scientific papers
Total synthesis and absolute configuration of macrocidin A, a cyclophane tetramic acid natural product
Yoshinari, Tomohiro,Ohmori, Ken,Schrems, Marcus G.,Pfaltz, Andreas,Suzuki, Keisuke
scheme or table, p. 881 - 885 (2010/05/02)
(Figure Presented) Stereocontrolled access to the cyclophane framework of macrocidin A has been achieved for the first time. The key steps include the iridium-catalyzed asymmetric hydrogenation without fission of the C-I bond, the macrolactam formation by intramolecular ketene trapping, and the Lacey-Dieckmann cyclization for the construction of the tetramic acid ring.
