1215337-96-4Relevant academic research and scientific papers
Use of the Diels-Alder cycloaddition of tetracyclone and internal aryl acetylenes for the synthesis of functionalized atropisomeric biaryls
Hapke, Marko,Gutnov, Andrey,Weding, Nico,Spannenberg, Anke,Fischer, Christine,Benkhaeuser-Schunk, Christian,Heller, Barbara
, p. 509 - 514 (2010)
The Diels-Alder cycloaddition reaction of tetracyclone and functionalized, internal aryl acetylenes gave access to a number of bulky atropisomeric biaryls in good to excellent: yield. The synthesis is convenient and yields the pure biaryls without tedious work-up and purification procedures. Exemplarily the atropisomers have been resolved via the diastereomers in an easy and efficient manner to yield the enantiomers.
