121568-35-2Relevant academic research and scientific papers
Preparation of Imidazoquinazolin-5(3H)-ones and Related Tricyclic Systems Using a Novel, Double Displacement Reaction
Peet, Norton P.,Malecha, James,LeTourneau, Michael E.,Sunder, Shyam
, p. 257 - 264 (2007/10/02)
New methodology is described for the construction of tricyclic heterocycles.Thus, a double displacement reaction of 1-(2-fluorobenzoyl)-2-methylthio-2-imidazoline (8a) with 1,1-dialkylhydrazines gave 10-substituted 2,10-dihydroimidazoquinazolin-5(3H)-ones in good yield.The corresponding 1-(2-nitrobenzoyl)-2-methylthio-2-imidazolines also underwent double displacement reactiones with hydrazines.Other tricyclics made using double displacement reactions were pyrimidoquinazolines, imidazopyridopyrimidines, and imidazopyrazolopyrimidines.Treatment of 8a with hydrazine hydrate or methylhydrazine gave products resulting from displacement, but did not afford fused benzotriazepinones.
