121572-28-9

Upstream product

• 109151-01-1 (3R,4S)-3-Ethyl-1-((R)-1-phenyl-ethyl)-4-trimethylsilanylethynyl-azetidin-2-one 
• 882-33-7 diphenyldisulfane 
• 121651-90-9 S-Phenyl (2R,3S)-2-ethyl-3-N-(R)-α-methylbenzylamino-5-trimethylsilyl-4-pentynethioate 
• 109150-99-4 (2S,3R)-2-Ethyl-3-((S)-1-phenyl-ethylamino)-5-trimethylsilanyl-pent-4-ynethioic acid S-phenyl ester 

Relevant academic research and scientific papers

A method for the synthesis of alkynyl phenyl sulfides from alkynyltrimethylsilanes. A novel, efficient synthesis of the thienamycin intermediate from 3(R)-hydroxybutyric acid

The mechanism of the one-pot conversion of β-amino thiol esters of type 3 to β-lactams of type 4 has been clarified, and it is proposed that the actual active species is a PhSSPh-CuOTf complex. Through the use of this novel reaction, an efficient synthesis of the thienamycin intermediate 2, starting with 3(R)-hydroxybutyric acid, has been achieved. Furthermore, the combined reagents (PhSSPh-CuOTf) have been demonstrated to be a powerful source of PhS+ through the conversion of several alkynyltrimethylsilanes to alkynyl phenyl sulfides.