1215809-13-4Relevant articles and documents
Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists
Dounay, Amy B.,Barta, Nancy S.,Campbell, Brian M.,Coleman, Corey,Collantes, Elizabeth M.,Denny, Lynne,Dutta, Satavisha,Gray, David L.,Hou, Dongfeng,Iyer, Rathna,Maiti, Samarendra N.,Ortwine, Daniel F.,Probert, Al,Stratman, Nancy C.,Subedi, Rajendra,Whisman, Tammy,Xu, Wenjian,Zoski, Kim
scheme or table, p. 1114 - 1117 (2010/06/15)
Preclinical studies suggest that compounds with dual norepinephrine reuptake inhibitor (NRI) and 5-HT1A partial agonist properties may provide an important new therapeutic approach to ADHD, depression, and anxiety. Reported herein is the discovery of a novel chemical series with a favorable NRI and 5-HT1A partial agonist pharmacological profile as well as excellent selectivity for the norepinephrine transporter over the dopamine transporter.
