121584-52-9

Basic information

• Product Name: 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A
• Synonyms: 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A
• CAS NO: 121584-52-9
• Molecular Formula: C₆₂H₁₀₉N₁₁O₁₄
• Molecular Weight: 515.72622
• Product Categories: Intermediates & Fine Chemicals;Peptides;Pharmaceuticals
• Mol File: 121584-52-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 1307.2±65.0 °C(Predicted)
• Appearance: White Solid
• Density: 1.032±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.22±0.70(Predicted)
• CAS DataBase Reference: 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A(121584-52-9)
• EPA Substance Registry System: 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A(121584-52-9)

Safety Data

• Hazardous Substances Data: 121584-52-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Intermediate for the preparation of Cyclosporin derivatives for the treatment of immune disorders

Upstream product

• 59865-13-3 cyclosporin A 
• 83602-41-9 O-acetyl-cyclosporin A 
• 59865-13-3 cyclosporine A 
• 83563-94-4 C₆₄H₁₁₃N₁₁O₁₃ 

Downstream Products

• 121584-08-5 C₆₉H₁₁₅N₁₁O₁₃ 
• 881008-20-4 C₆₉H₁₁₄ClN₁₁O₁₃ 
• 881007-57-4 C₆₉H₁₁₄ClN₁₁O₁₃ 
• 121886-75-7 [(3R,4R)-3-hydroxy-4-methyl-6-(2-hydroxyethyl)-N-MeNle]-1-cyclosporin 

Relevant articles and documents

Organozirconium chemistry on cyclosporin: A novel process for the highly stereoselective synthesis of (E)-ISA247 (voclosporin) and close analogues

Application of organozirconium chemistry to cyclosporin has led to the development of a novel process for the highly stereoselective synthesis of the E-isomer of ISA247 (voclosporin), which is a potent immunosuppressive agent currently in late stage human clinical trials for treatment of psoriasis, prevention of kidney transplant rejection, and ophthalmic indications. Synthesis of deuterated analogues of ISA247 and a cyclosporin triene analogue using the same methodology is also described. Georg Thieme Verlag Stuttgart. New York.

NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF

A compound of the Formula (I) is disclosed: (I) or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification. Also described are a pharmaceutical composition comprising the same and a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, lung, and liver, and kindey diseases, and hair loss using the same.

Chemical tagging of a drug target using 5-sulfonyl tetrazole

Irreversible modification is one of the most promising strategies to identify cellular receptors of bioactive small molecules. Here we report that receptor proteins can be chemically tagged using a 5-sulfonyl tetrazole probe. 5-Sulfonyl tetrazole easily a