1215858-80-2

Upstream product

• 321681-28-1 2-bromo-1-(2-bromo-4,5-dimethoxyphenyl)-ethanone 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 
• 74746-10-4 1-(2-bromo-4,5-dimethoxyphenyl)ethanone 

Downstream Products

• 1215858-79-9 (Z)-1-(2-bromo-4,5-dimethoxyphenyl)ethanone oxime 
• 1616606-35-9 C₁₄H₁₉BrN₂O₃ 
• 1609071-67-1 C₁₄H₁₈N₂O₃ 

Relevant academic research and scientific papers

2 - Substituted cephem compound-containing pharmaceutical composition

PROBLEM TO BE SOLVED: To provide a cephem compound which has a strong antimicrobial activity, in particular effective against various β-lactamase producing Gram negative bacteria, and a composition comprising the compound.SOLUTION: The present invention provides a pharmaceutical composition comprising a compound represented by formula (I), an ester at a carboxyl group, an amino-protected compound when the amino is present on a ring in the 7-side chain, or a pharmaceutically acceptable salt thereof.

CEPHEM COMPOUND

A compound of the formula: wherein, W is —CH2? etc.; U is —S? etc.; R1 is substituted or unsubstituted carbocyclyl etc.; R2A and R2B is a) or b) described in the specification; R3 is a hydrogen atom etc.; R11 is carboxylate anion (—COO?) etc.; L is substituted or unsubstituted lower alkylene etc., E is a substituted or unsubstituted divalent group containing quaternary ammonium ion; G is a single bond etc.; D is —C(═O)—C(═O)—NR6— etc.; R10 1) to 3) described in specification; or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof.

2 SUBSTITUTED CEPHEM COMPOUNDS

The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

Copper-catalyzed cyclization of Z-oximes into 3-methyl-1,2-benzisoxazoles

A practical and effective room temperature copper-catalyzed cyclization of Z-oximes is developed. 3-Methyl-1,2-benzisoxazoles are obtained in 58-79% yields. Also, the Z-selective synthesis of o-bromo acetophenone oximes is presented for the first time.