1215864-44-0

Basic information

• Product Name: 2'-(3-chloro-2-fluorophenyl)-7'-methoxyspiro[1,3-oxazole-4,9'-xanthen]-2-amine
• CAS NO: 1215864-44-0
• Molecular Weight: 410.832
• Mol File: 1215864-44-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2'-(3-chloro-2-fluorophenyl)-7'-methoxyspiro[1,3-oxazole-4,9'-xanthen]-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-(3-chloro-2-fluorophenyl)-7'-methoxyspiro[1,3-oxazole-4,9'-xanthen]-2-amine(1215864-44-0)
• EPA Substance Registry System: 2'-(3-chloro-2-fluorophenyl)-7'-methoxyspiro[1,3-oxazole-4,9'-xanthen]-2-amine(1215864-44-0)

Safety Data

• Hazardous Substances Data: 1215864-44-0(Hazardous Substances Data)

Upstream product

• 1215864-24-6 2′-bromo-7′-methoxyspiro[1,3-oxazole-4,9′-xanthen]-2-amine 
• 352535-82-1 (3-chloro-2-fluorophenyl) boronic acid 
• 1215864-23-5 2-bromo-7-methoxy-9-methylene-9H-xanthene 
• 65193-10-4 2-bromo-7-methoxy-9H-xanthen-9-one 
• 1215864-17-7 2-(4-bromophenoxy)-5-methoxybenzoic acid 

Relevant articles and documents

Structure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and cns penetrable BACE inhibitors for the treatment of alzheimers disease

A structure- and property-based drug design approach was employed to identify aminooxazoline xanthenes as potent and selective human β-secretase inhibitors. These compounds exhibited good isolated enzyme, cell potency, and selectivity against the structurally related aspartyl protease cathepsin D. Our efforts resulted in the identification of a potent, orally bioavailable CNS penetrant compound that exhibited in vivo efficacy. A single oral dose of compound 11a resulted in a significant reduction of CNS Aβ40 in naive rats.