121593-77-9

Basic information

• Product Name: FMOC-NLE-OPFP
• Synonyms: FMOC-NORLEUCINE-OPFP;FMOC-NLE-OPFP;FMOC-L-NORLEUCINE PENTAFLUOROPHENYL ESTER;FMOC-L-2-AMINOHEXANOIC ACID-OPFP;FMOC-L-2-AMINOHEXANOIC ACID PENTAFLUOROPHENYL ESTER;N-ALPHA-FMOC-L-NORLEUCINE PENTAFLUOROPHENYL ESTER;NALPHA-9-Fluorenylmethoxycarbonyl-L-norleucine pentafluorophenyl ester
• CAS NO: 121593-77-9
• Molecular Formula: C27H22F5NO4
• Molecular Weight: 519.46
• Product Categories: Amino Acids
• Mol File: 121593-77-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: FMOC-NLE-OPFP(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-NLE-OPFP(121593-77-9)
• EPA Substance Registry System: FMOC-NLE-OPFP(121593-77-9)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 121593-77-9(Hazardous Substances Data)

Usage

Description

FMOC-NLE-OPFP is a specialized chemical compound that integrates the FMOC (9-fluorenylmethoxycarbonyl) protective group, the amino acid NLE (norleucine), and the OPFP (2,2,5,7,8-pentamethyl-6-chlorochromane-2-sulfonyl) protecting group. FMOC-NLE-OPFP plays a pivotal role in the synthesis of peptides and proteins, serving as a critical building block. The FMOC group shields the N-terminus of the amino acid, while the OPFP group safeguards the side chain of the NLE residue, making FMOC-NLE-OPFP an essential component in the realms of organic chemistry and biochemistry for crafting intricate peptides and proteins intended for research and pharmaceutical applications.

Uses

Used in Organic Chemistry:
FMOC-NLE-OPFP is used as a key building block for the synthesis of complex peptides and proteins. Its incorporation facilitates the stepwise assembly of peptide chains, providing a protected and controlled environment for the reaction to proceed.
Used in Biochemistry:
FMOC-NLE-OPFP is utilized as a component in the creation of bioactive peptides and proteins for research purposes. It aids in the development of novel biocompounds with potential applications in various biological studies.
Used in Pharmaceutical Industry:
FMOC-NLE-OPFP is employed as a crucial intermediate in the production of therapeutic peptides and proteins. Its role in protecting specific functional groups ensures the successful synthesis of bioactive molecules with desired pharmacological properties.
Used in Peptide Synthesis:
FMOC-NLE-OPFP is used as a protected amino acid in solid-phase peptide synthesis. The protective groups allow for selective deprotection and coupling reactions, enabling the synthesis of peptides with specific sequences and functionalities.