121611-65-2Relevant academic research and scientific papers
Total Synthesis of tricladins a and b and identification of their absolute configuration
Zhao, He,Huang, Zhongping,Chen, Wen
, p. 11290 - 11294 (2014)
A concise synthesis of both (S)- and (R)-enantiomers of tricladins A and B from l-Boc alanine was achieved. The diastereomeric intermediates were separated by chiral column chromatography, and the absolute configuration of the 2-position was assigned by observed NOE interactions with the known stereogenic center at the 5-position. By comparison of all synthesized final enantiomers with the corresponding natural products, we concluded that the natural tricladins A and B must have the (R)-configuration.
Additivity or cooperativity: Which model can predict the influence of simultaneous incorporation of two or more functionalities in a ligand molecule?
Nasief, Nader N.,Hangauer, David
, p. 897 - 915 (2015/05/27)
Predicting how binding affinity responds to ligand structural modifications in structure-activity relationship studies (SAR) is a major challenge in medicinal chemistry. This is particularly true when two or more of these modifications are carried out simultaneously. In this study, we present binding affinity data from several series of thermolysin inhibitors in which simultaneous structural modifications were investigated to determine whether they are cooperative or additive. Data revealed that, while additivity is at work in some cases, cooperativity is more commonly demonstrated. Cooperativity and additivity were then correlated with ligand descriptors, such as the spacing and the topological features of the modified groups, in a manner that may provide guidance as to when each model should be utilized. Cooperativity was particularly associated with contiguous groups and small unbranched hydrophobic side chain. Additivity, on the other hand, was associated with moderately distant hydrophobic group combinations and side chain branching. Such correlations can improve the predictability of SAR studies and can provide a starting point for additional investigations that may lead to further significant enhancements in the current scoring functions.
Condensation of α-Amino Acid with Amine in the Absence of a Coupling Agent
Yamaguchi, Jun-Ichi,Nagai, Shinya,Fukuoka, Emi,Suyama, Takayuki
, p. 830 - 831 (2007/10/03)
Treatment of N-(4-nitrophenoxycarbonyl)amino acid with an equimolar amount of amine in the absence of a coupling agent gave the corresponding α-amino acid amide in high yield.
REGIOSELECTIVE SYNTHESIS OF ISOPROPENYL ESTERS BY RUTHENIUM CATALYSED ADDITION OF N-PROTECTED AMINO-ACIDS TO PROPINE
Ruppin, Christophe,Dixneuf, Pierre H.,Lecolier, Serge
, p. 5365 - 5368 (2007/10/02)
A general route to isopropenyl esters of N-protected amino-acids is reported, by direct addition of Z-N or Boc-N amino acids to propyne catalysed by ruthenium(II) complexes; it takes place without racemization.The isopropenyl esters are activated towards
