121627-17-6

Basic information

• Product Name: 6,6'-[(3,3'-Di-t-butyl-5,5'-dimethoxy-1,1'-biphenyl-2,2'-diyl)bis(oxy)]bis(dibenzo[d,f][1,3,2]dioxaphosphepin)hemiethylacetateadduct,min.95%BIPHEPHOS
• Synonyms: 6,6'-[(3,3'-Di-t-butyl-5,5'-dimethoxy-1,1'-biphenyl-2,2'-diyl)bis(oxy)]bis(dibenzo[d,f][1,3,2]dioxaphosphepin)hemiethylacetateadduct,min.95%BIPHEPHOS;6,6μ-[(3,3μ-Di-tert-butyl-5,5μ-dimethoxy-1,1μ-biphenyl-2,2μ-diyl)bis(oxy)]bis(dibenzo[d,f][1,3,2]dioxaphosphepin);BiPhePhos;6,6'-[(3,3'-Di-t-butyl-5,5'-dimethoxy-1,1'-biphenyl-2,2'-diyl)bis(oxy)] bis(dibenzo[d,f][1,3,2]dioxaphosphepin) hemi ethyl acetate adduct, min. 95% BIPHEPOS;6,6'-((3,3'-di-tert-butyl-5,5'-dimethoxy-[1,1'-biphenyl]-2,2'-diyl)bis(oxy))didibenzo[d,f][1,3,2]dioxaphosphepine;2,2'-Bis[(1,1'-biphenyl-2,2'-diyl)phosphite]-3,3'-di-tert-butyl-5,5'-dimethoxy-1,1'-biphenyl;6,6'-[[3,3'-Bis(1,1-dimethylethyl)-5,5'-dimethoxy[1,1'-biphenyl]-2,2'-diyl]bis(oxy)]bis[dibenzo[d,f][1,3,2]dioxaphosphepin];6,6'-[(3,3'-Di-tert-butyl-5,5'-dimethoxy-1,1'-biphenyl-2,2'-diyl)bis(oxy)]bis(dibenzo[d,f][1,3,2]dioxaphosphepin)hemi ethyl acetate adduct
• CAS NO: 121627-17-6
• Molecular Formula: C₄₆H₄₄O₈P₂
• Molecular Weight: 786.794
• Product Categories: Achiral Phosphine;Aryl Phosphine
• Mol File: 121627-17-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 128-133 °C
• Boiling Point: 768.263 °C at 760 mmHg
• Flash Point: 530.131 °C
• Appearance: white to off-white/Powder
• Density: 1.258 at 20℃
• Storage Temp.: -20°C
• Sensitive: air sensitive, moisture sensitiv
• CAS DataBase Reference: 6,6'-[(3,3'-Di-t-butyl-5,5'-dimethoxy-1,1'-biphenyl-2,2'-diyl)bis(oxy)]bis(dibenzo[d,f][1,3,2]dioxaphosphepin)hemiethylacetateadduct,min.95%BIPHEPHOS(CAS DataBase Reference)
• NIST Chemistry Reference: 6,6'-[(3,3'-Di-t-butyl-5,5'-dimethoxy-1,1'-biphenyl-2,2'-diyl)bis(oxy)]bis(dibenzo[d,f][1,3,2]dioxaphosphepin)hemiethylacetateadduct,min.95%BIPHEPHOS(121627-17-6)
• EPA Substance Registry System: 6,6'-[(3,3'-Di-t-butyl-5,5'-dimethoxy-1,1'-biphenyl-2,2'-diyl)bis(oxy)]bis(dibenzo[d,f][1,3,2]dioxaphosphepin)hemiethylacetateadduct,min.95%BIPHEPHOS(121627-17-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 121627-17-6(Hazardous Substances Data)

Usage

Reactions

With rhodium forms a highly active catalyst for the hydroformylation of α-olefins. The hydroformylation of functionalized α-olefins is highly regioselective. The sterically demanding ligand increases n/iso ratio by reducing rhodium interaction with heteroatom functionality. Ligand used in tandem reaction sequences where high n/iso ratio is desired in the hydroformylation step.

Upstream product

• 16611-68-0 6-chloro-dibenzo[d,f][1,3,2]-dioxaphosphepin 
• 14078-41-2 2,2'-dihydroxy-3,3'-di-tert-butyl-5,5'-dimethoxy-1,1'-biphenyl 
• 1806-29-7 2,2'-dihydroxybiphenyl 

Relevant articles and documents

Preparation method of bidentate phosphite compound in microchannel reactor

The invention discloses a preparation method of a bidentate phosphite compound in a microchannel reactor, which is characterized by comprising the following steps of dissolving phosphorus trichloride in a solvent A to prepare a solution A, dissolving substituted diphenol I and an acid-binding agent in a solvent B to prepare a solution B, and enabling the two solutions to enter the microchannel reactor under the action of a feed pump to react to obtain a reaction solution A, dissolving substituted diphenol II and an acid-binding agent in a solvent C to prepare a solution C, enabling the solution C to enter the microchannel reactor under the action of a feeding pump to be mixed with the reaction liquid A for reaction, obtaining a crude product solution, and performing post-treatment and recrystallization to obtain the bidentate phosphite compound. No precipitate is generated in the whole reaction process, so that the method is more suitable for a micro-channel reaction technology, the problem of micro-channel blockage caused by generation of a large amount of precipitate is avoided, the whole reaction process can be more continuously and stably operated in the micro-channel reactor, and the service life of the micro-channel reactor is greatly prolonged.

Diphosphite synthesis method

The invention discloses a diphosphite synthesis method. According to the diphosphite synthesis method, a tested dosage of phosphorus trichloride, 2,2'-diphenol and 3,3'-di-tert-butyl-5,5'-dimethoxy-2,2'-diphenol are used as raw materials, the phosphorus trichloride is dissolved in an organic solvent to prepare a solution, then the solution is added into a 2,2'-diphenol and organic alkali dissolved organic solution under stirring, and the reaction solution is continuously stirred for several hours after addition of the phosphorus trichloride solution is completed; a 3,3'-di-tert-butyl-5,5'-dimethoxy-2,2'-diphenol dissolved organic solution is added into the reaction solution, the reaction solution is continuously stirred for several hours after adding is completed, then heating is performed to reach the temperature of 80-120 DEG C, and reflux is performed for several hours; the reaction liquid is cooled to reach room temperature after reaction is completed, filtration and filter cake washing are performed, filtrates are mixed and then are evaporated and concentrated to obtain solid, the solid is washed with acetonitrile, and recrystallization is performed to obtain a product. The diphosphite synthesis method has the advantages of being high in diphosphite yield, small in phosphorus trichloride usage amount, few in by-products, short in reaction time, simple in aftertreatment and the like.

METHOD FOR THE PURIFICATION OF BIPHEPHOS

The invention relates to a process for the purification of 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′diyl)bis(oxy)]bis(dibenzo[d,f][1,3,2]dioxaphosphepin), abbreviation: biphephos (see formula 1).