121643-46-7

Basic information

• Product Name: 6-chloro-2-Methoxynicotinonitrile
• Synonyms: 6-chloro-2-Methoxynicotinonitrile;6-chloro-2-methoxy-3-Pyridinecarbonitrile
• CAS NO: 121643-46-7
• Molecular Formula: C₇H₅ClN₂O
• Molecular Weight: 168.5804
• Mol File: 121643-46-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 272.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.30±0.10(Predicted)
• CAS DataBase Reference: 6-chloro-2-Methoxynicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-Methoxynicotinonitrile(121643-46-7)
• EPA Substance Registry System: 6-chloro-2-Methoxynicotinonitrile(121643-46-7)

Safety Data

• Hazardous Substances Data: 121643-46-7(Hazardous Substances Data)

Usage

General Description

6-chloro-2-Methoxynicotinonitrile is an organic compound with the molecular formula C7H6ClNO. It is a derivative of nicotinic acid and contains a chlorine atom and a methoxy group attached to a pyridine ring. This chemical has a variety of potential applications, including as an intermediate for the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of dyes and pigments. Additionally, 6-chloro-2-Methoxynicotinonitrile may have biological activity, making it a subject of interest for research in the pharmaceutical industry. Its chemical structure and properties make it a versatile compound with potential uses in various industries.

Upstream product

• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 40381-90-6 2,6-dichloro-3-pyridinecarbonitrile 

Downstream Products

• 1213790-37-4 tert-butyl 4-bromo-3-methylphenyl(5-cyano-6-methoxypyridin-2-yl)carbamate 

Relevant articles and documents

SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

Neurotrophic factor tyrosine kinase receptor inhibitor

The invention provides a neurotrophic factor tyrosine kinase receptor inhibitor. The tyrosine kinase receptor inhibitor provided by the invention has a tricyclic parent core structure, can inhibit theactivity of Trk kinase and can be used for treating mammalian diseases mediated by the Trk kinase.

Transformations of trichloromethyl groups during reactions of 3-trichloromethylpyridines with methoxide

When methoxide ion attacks an unsubstituted 2- or 6-position of a 3-trichloromethylpyridine, a hydrogen shift leads to a methoxy-substituted 3-dichloromethylpyridine. Further reaction of the dichloromethyl group with methoxide gives the corresponding acetal. This type of reaction has been applied to several chlorinated 3-trichloromethylpyridines and to 3- trichloromethylpyridine itself; a convenient synthesis of the latter is described.