121654-45-3

Upstream product

• 98123-85-4 1-(3-phenylpropyl)-4-benzyl-2-hydroxy-6-oxopiperazine 
• 98123-84-3 1-(3-phenylpropyl)-4-benzyl-piperazine-2,6-dione 
• 3987-53-9 N-benzyliminodiacetic acid 
• 2038-57-5 3-Phenylpropan-1-amine 

Downstream Products

• 98123-67-2 2-Cyclohexanecarbonyl-2,3,6,7,8,12b-hexahydro-1H-benzo[3,4]azepino[1,2-a]pyrazin-4-one 
• 98123-66-1 2-Cyclohexanecarbonyl-2,3,6,7,8,12b-hexahydro-1H-benzo[3,4]azepino[1,2-a]pyrazin-4-one 
• 121654-80-6 Cyclohexyl-(3,4,6,7,8,12b-hexahydro-1H-benzo[3,4]azepino[1,2-a]pyrazin-2-yl)-methanone 
• 98123-74-1 2-(triphenylmethyl)-4-thioxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine 
• 121654-85-1 2-(triphenylmethyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine 
• 121654-65-7 2-(4-Nitro-benzoyl)-2,3,6,7,8,12b-hexahydro-1H-benzo[3,4]azepino[1,2-a]pyrazin-4-one 
• 121654-67-9 2-(3-Nitro-benzoyl)-2,3,6,7,8,12b-hexahydro-1H-benzo[3,4]azepino[1,2-a]pyrazin-4-one 
• 121654-74-8 2-(4-Dimethylamino-benzoyl)-2,3,6,7,8,12b-hexahydro-1H-benzo[3,4]azepino[1,2-a]pyrazin-4-one 
• 98123-53-6 2-(cyclohex-3-enylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-a-][2]benzazepine 
• 121654-62-4 2-(4-Methoxy-benzoyl)-2,3,6,7,8,12b-hexahydro-1H-benzo[3,4]azepino[1,2-a]pyrazin-4-one 
• 121654-66-8 2-(4-Amino-benzoyl)-2,3,6,7,8,12b-hexahydro-1H-benzo[3,4]azepino[1,2-a]pyrazin-4-one 
• 121654-68-0 2-(3-Amino-benzoyl)-2,3,6,7,8,12b-hexahydro-1H-benzo[3,4]azepino[1,2-a]pyrazin-4-one 
• 121654-69-1 2-(4-Hydroxy-benzoyl)-2,3,6,7,8,12b-hexahydro-1H-benzo[3,4]azepino[1,2-a]pyrazin-4-one 
• 121654-63-5 2-(4-Chloro-benzoyl)-2,3,6,7,8,12b-hexahydro-1H-benzo[3,4]azepino[1,2-a]pyrazin-4-one 

Relevant academic research and scientific papers

Synthesis and Anthelmintic Activity of a Series of Pyrazinobenzazepine Derivatives

A series of 1,2,3,4,6,7,8,12b-octahydropyrazinobenzazepine derivatives was prepared and the cestocidal activity of the compounds evaluated in an in vitro Taenia crassiceps screen.Many of these derivatives proved to be highly active, and 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazinobenzazepine, epsiprantel (BAN) (22), was selected for further development.The structure-activity relationships are discussed.

Benzazepines, and their use as anthelminthics

A compound of formula (I): STR1 in which R is optionally substituted phenyl; C3-8 cycloalkyl; C5-8 cycloalkenyl; C1-8 alkyl which may be straight or branched; C2-8 alkenyl which may be straight or branched; 5- or 6- membered heterocyclyl; or optionally substituted phenyl C1-4 alkyl, each of Y and Z, which may be the same or different, is oxygen or sulphur; and X is --CH2 -- or oxygen, a process for the preparation of such compounds and their use in human and veterinary medicine.