121654-56-6

Basic information

• Product Name: 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino(2,1-a)(2)benzazepine
• Synonyms: 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino(2,1-a)(2)benzazepine;Coopb
• CAS NO: 121654-56-6
• Molecular Formula: C20H26 N2 O2
• Molecular Weight: 0
• Mol File: 121654-56-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 553.7°Cat760mmHg
• Flash Point: 255.3°C
• Appearance: /
• Density: 1.2g/cm³
• CAS DataBase Reference: 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino(2,1-a)(2)benzazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino(2,1-a)(2)benzazepine(121654-56-6)
• EPA Substance Registry System: 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino(2,1-a)(2)benzazepine(121654-56-6)

Safety Data

• Hazardous Substances Data: 121654-56-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H26N2O2/c23-19-14-21(20(24)16-8-2-1-3-9-16)13-18-17-11-5-4-7-15(17)10-6-12-22(18)19/h4-5,7,11,16,18H,1-3,6,8-10,12-14H2

Upstream product

• 133958-40-4 1-(3-Phenylpropyl)-6-hydroxypiperazin-2-one 
• 98123-61-6 2H-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine 
• 121654-45-3 2-benzyl-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine 
• 98123-84-3 1-(3-phenylpropyl)-4-benzyl-piperazine-2,6-dione 
• 98123-85-4 1-(3-phenylpropyl)-4-benzyl-2-hydroxy-6-oxopiperazine 
• 2038-57-5 3-Phenylpropan-1-amine 
• 98123-62-7 2H-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 98123-64-9 2H-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine 
• 52221-92-8 3-(2-bromo-phenyl)-propan-1-ol 
• 1372607-34-5 1-cyclohexanecarbonyl-3-methoxy-1,2-dihydropyrazine 
• 7664-93-9 sulfuric acid 
• 106206-88-6 1-(3-Phenylpropyl)-4-cyclohexylcarbonyl-6-hydroxypiperazin-2-one 
• 106206-86-4 1-(3-phenylpropyl)-piperazine-2,6-dione 

Relevant articles and documents

A palladium-catalyzed intramolecular Heck/Hydrogenation approach towards the synthesis of praziquantel

Starting from 3-methoxy N-acylpyrazinium salts, a new approach towards the synthesis of the antischistosomal drug praziquantel (PZQ) has been developed. Utilization of a palladium-catalyzed intramolecular Heck reaction to form dehydro-PZQ followed by a Hydrogenation step, in a stepwise or one-pot manner, allowed for the gram scale synthesis of PZQ in 4 or 5 steps and in good overall yields. This methodology proved to be well suited for generating the pyrazino[1,2-a] isoindole and pyrazino[1,2-a] benzazepine analogues of PZQ.

SYNTHESIS OF TRICYCLIC SYSTEMS INCORPORATING THE AZEPINE RING

Some tricyclic compounds (derivatives of pyrazinobenzazepine, diazepinoisoquinoline, and some pyrimidoisoquinolines) which are analogs of the anthelmintic praziquantel have been synthesized.

Benzazepines, and their use as anthelminthics

A compound of formula (I): STR1 in which R is optionally substituted phenyl; C3-8 cycloalkyl; C5-8 cycloalkenyl; C1-8 alkyl which may be straight or branched; C2-8 alkenyl which may be straight or branched; 5- or 6- membered heterocyclyl; or optionally substituted phenyl C1-4 alkyl, each of Y and Z, which may be the same or different, is oxygen or sulphur; and X is --CH2 -- or oxygen, a process for the preparation of such compounds and their use in human and veterinary medicine.