1216552-75-8

Basic information

• Product Name: 2-Azido-1-(chloroMethyl)ethyl Carbonic Acid Phenyl Ester
• CAS NO: 1216552-75-8
• Molecular Formula: C10H10ClN3O3
• Molecular Weight: 255.6577
• Product Categories: Aromatics
• Mol File: 1216552-75-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Azido-1-(chloroMethyl)ethyl Carbonic Acid Phenyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azido-1-(chloroMethyl)ethyl Carbonic Acid Phenyl Ester(1216552-75-8)
• EPA Substance Registry System: 2-Azido-1-(chloroMethyl)ethyl Carbonic Acid Phenyl Ester(1216552-75-8)

Safety Data

• Hazardous Substances Data: 1216552-75-8(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

Upstream product

• 1885-14-9 phenyl chloroformate 
• 180587-77-3 (2R)-1-azido-3-chloropropan-2-ol 
• 681225-50-3 (2S)-1-azido-3-chloropropan-2-ol 

Downstream Products

• 1349248-79-8 4-{4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one 
• 169048-83-3 (5S)-5-(chloromethyl)-1,3-oxazolidin-2-one 

Relevant articles and documents

PROCESSES FOR THE PREPARATION OF 4-{4-[5(S)-(AMINOMETHYL)-2-OXO-1,3-OXAZOLIDIN-3-YL]PHENYL} MORPHOLIN-3-ONE

The present invention provides simple, eco-friendly, cost-effective, reproducible, robust and industrial processes for the preparation of intermediate compound 4-{4-[5(S)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one (II). The present invention also provides novel intermediates and their use in the synthesis of morpholinone oxazolidine derivatives.

A novel and short convergent approach for N-aryl-5-aminomethyl-2- oxazolidinone derivatives Linezolid and DUP-721

A new convergent and short approach for oxazolidinone class of antibacterial agents, Linezolid and DUP-721, has been achieved by condensing 3-chloro-2-((phenoxycarbonyl)oxy) propyl azide with aryl amine followed by reductive acetylation. This one pot approach for N-aryl-5-azidomethyl- 2-oxazolidinone could provide access for rapid preparation of various oxazolidinone analogues.