1216771-62-8

Basic information

• Product Name: 4-(2-amino-5-(thiazol-4-yl)pyridin-3-yl)benzamide
• CAS NO: 1216771-62-8
• Molecular Weight: 296.352
• Mol File: 1216771-62-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-amino-5-(thiazol-4-yl)pyridin-3-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-amino-5-(thiazol-4-yl)pyridin-3-yl)benzamide(1216771-62-8)
• EPA Substance Registry System: 4-(2-amino-5-(thiazol-4-yl)pyridin-3-yl)benzamide(1216771-62-8)

Safety Data

• Hazardous Substances Data: 1216771-62-8(Hazardous Substances Data)

Upstream product

• 1216771-56-0 4-(2-amino-5-bromopyridin-3-yl)benzamide 
• 173979-01-6 4-(tributylstannyl)-1,3-thiazole 

Relevant articles and documents

Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2

5-(Hetero)aryl-3-(4-carboxamidophenyl)-2-aminopyridine inhibitors of CHK2 were identified from high throughput screening of a kinase-focussed compound library. Rapid exploration of the hits through straightforward chemistry established structure-activity relationships and a proposed ATP-competitive binding mode which was verified by X-ray crystallography of several analogues bound to CHK2. Variation of the 5-(hetero)aryl substituent identified bicyclic dioxolane and dioxane groups which improved the affinity and the selectivity of the compounds for CHK2 versus CHK1. The 3-(4-carboxamidophenyl) substituent could be successfully replaced by acyclic ω-aminoalkylamides, which made additional polar interactions within the binding site and led to more potent inhibitors of CHK2. Compounds from this series showed activity in cell-based mechanistic assays for inhibition of CHK2.