121683-05-4Relevant academic research and scientific papers
9-(2-Aryloxyethyl) derivatives of adenine - A new class of non-nucleosidic antiviral agents
Petrov,Ozerov,Novikov,Pannecouque,Balzarini,De Clercq
, p. 1218 - 1226 (2007/10/03)
New 9-(aryloxyalkyl) derivatives of adenine have been prepared by alkylation of adenine with tosylates, bromides, and α-chloro ethers containing terminal aromatic fragments in anhydrous DMF in the presence of potassium carbonate. The compounds of the 9-(2-phenoxyethyl)adenine series appear to be highly reactive against cytomegaloviruses of mankind in vitro, while derivatives of 9-(2-benzyloxyethyl)adenine demonstrate anti-HIV-1 activity. Compounds with shorter or longer chains, and also compounds which do not have aromatic fragments at the ends of the chains, do not possess antiviral activity.
Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder)
Howson, William,Taylor, Edwin Michael,Parsons, Michael Edward,Novelli, Riccardo,Wilczynska, Maria Aleksandra,Harris, Deborah Tracy
, p. 433 - 440 (2007/10/02)
This paper describes studies carried out on a series of ATP analogues on the guinea pig bladder, a tissue reported to possess purinergic P2X-receptors.Optimisation of the pharmacological experimental technique enabled reproducible responses to ATP to be obtained in the 0.2-100 μM concentration range and the potencies of ATP analogues relative to ATP to be accurately determined.Alterations of the three main parts of the ATP molecule, i.e., the triphosphate, ribose and base, suggest that the triphosphate group is responsible for the efficacy of the agonist, whereas the ribose and adenine moieties are associated with affinity. quantitative analysis / ATP / purinergic / P2X-receptors / guinea pig bladder
