121704-78-7Relevant articles and documents
Discovery of novel VX-809 hybrid derivatives as F508del-CFTR correctors by molecular modeling, chemical synthesis and biological assays
Parodi, Alice,Righetti, Giada,Pesce, Emanuela,Salis, Annalisa,Tasso, Bruno,Urbinati, Chiara,Tomati, Valeria,Damonte, Gianluca,Rusnati, Marco,Pedemonte, Nicoletta,Cichero, Elena,Millo, Enrico
, (2020/10/02)
Cystic fibrosis (CF) is the autosomal recessive disorder most recurrent in Caucasian populations. It is caused by different mutations in the cystic fibrosis transmembrane regulator protein (CFTR) gene, with F508del being the most common. During the last y
Oral Hypoglycemic Agents. Discovery and Structure-Activity Relationships of Phenacylimidazolium Halides
Dominianni, Samuel J.,Yen, Terence T.
, p. 2301 - 2306 (2007/10/02)
Blood glucose levels in viable, yellow, obese, diabetic mice are reduced following oral administration of phenacylimidazolium halides.Compounds 2 and 3 produced reductions of ca. 40percent 2 h after doses of 100 mg/kg po.Since these mice do not respond to sulfonylureas, the glucose-lowering activity of phenacylimidazolium salts in this model suggests a mechanism other than that of stimulating insulin secretion.Only phenacylimidazolium halides with electron-donating groups were active; other azolium salts or variations in the phenacyl portion (alterations in the keto function; chain lengthening or extensive branching) produced inactive compounds.