1217185-04-0Relevant articles and documents
RETRACTED ARTICLE: A magnetic core-shell composite structure modified with Ru-based chemosensor for site-specific oxygen sensing: Design strategy, characterization and performance
Lin, Chen,Zhigang, Fang
, p. 149 - 157 (2017)
This effort focused on a site-specific composite sample with core-shell structure for oxygen sensing purpose, using Fe3O4particles as magnetic core, silica molecular sieve MCM-41 as supporting shell and a Ru(II)-based complex having
Apoptosis in?vitro in PC-12 cells induced by an organometallic Ir(III) complex through a ROS-mediated mitochondrial pathway
Hong, Xian-Lan,Zhou, Yu-Huan,Zeng, Chuan-Chuan,Wu, Xiao-Chao,Liu, Yun-Jun
, p. 312 - 320 (2017)
An Ir(III) organometallic complex, [Ir(ppy)2(paip)]PF6 (1), (ppy and paip denote 2-phenylpyridine and 2-(4-aminophenyl) imidazo [4,5-f] [1,10] phenanthroline, respectively) was synthesized and characterized by elemental analysis, ESI-MS, 1H and 13C NMR. The cytotoxic activity in vitro of the complex was evaluated by MTT (MTT = (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)) method. The complex shows higher cytotoxic activity against PC-12 cells than cisplatin. The intracellular ROS generation and mitochondrial membrane potential (MMP) changes were determined by fluorescent microscope and flow cytometry. The cellular uptake and location of complex 1, as well as cell cycle distribution and matrigel invasion in PC-12 cells treated with the complex were investigated. Meanwhile, Bcl-2 family proteins expression was also explored by western blot. The results indicate that the complex shows efficient cellular uptake and cumulates in nucleus as well as in mitochondria, and inhibits both the growth at G0/G1 phase and the invasion in extracellular matrix. It is rationally concluded that complex 1 induces apoptosis in PC-12 cell through a ROS-mediated mitochondrial dysfunction pathway with an increase in ROS level and a decrease in MMP.
Towards a core-shell composite structure loaded with a Ru-based sensing probe and its improved site-specific oxygen sensing performance
Yuqing, Zhao,Yuping, Tong
, p. 146 - 153 (2016)
The following paper was devoted to a site-specific core-shell composite structure loaded with a Ru-based sensing probe, using Fe3O4 particles as core and silica molecular sieve MCM-41 as shell, respectively. A diamine ligand with lar
Eu(iii)-coupled graphene oxide as a luminescent material
Gou, Galian,Ren, Ren,Li, Shuwen,Guo, Shujing,Dong, Zhengping,Xie, Miao,Ma, Jiantai
, p. 3861 - 3864 (2013)
A graphene-inorganic hybrid material has been fabricated by coupling Eu(iii) complexes onto graphene oxide (GO) (denoted as Eu-GO hereafter). Successful coupling has been verified by 1H NMR, CHN elemental analysis, inductively coupled plasma-at
A Click Chemistry Approach to Developing Molecularly Targeted DNA Scissors
Carell, Thomas,Crisp, Antony L.,Kellett, Andrew,Lauria, Teresa,Müller, Markus,McKee, Vickie,Slator, Creina,Stazzoni, Samuele
, p. 16782 - 16792 (2020)
Nucleic acid click chemistry was used to prepare a family of chemically modified triplex forming oligonucleotides (TFOs) for application as a new gene-targeted technology. Azide-bearing phenanthrene ligands—designed to promote triplex stability and copper binding—were ‘clicked’ to alkyne-modified parallel TFOs. Using this approach, a library of TFO hybrids was prepared and shown to effectively target purine-rich genetic elements in vitro. Several of the hybrids provide significant stabilisation toward melting in parallel triplexes (>20 °C) and DNA damage can be triggered upon copper binding in the presence of added reductant. Therefore, the TFO and ‘clicked’ ligands work synergistically to provide sequence-selectivity to the copper cutting unit which, in turn, confers high stabilisation to the DNA triplex. To extend the boundaries of this hybrid system further, a click chemistry-based di-copper binding ligand was developed to accommodate designer ancillary ligands such as DPQ and DPPZ. When this ligand was inserted into a TFO, a dramatic improvement in targeted oxidative cleavage is afforded.
Effect of ancillary ligands on the interaction of ruthenium(II) complexes with the triplex RNA poly(U)·poly(A)?poly(U)
Li, Jia,Sun, Yanmei,Xie, Lingjun,He, Xiaojun,Tan, Lifeng
, p. 56 - 63 (2015)
Two new Ru(II) complexes with 1,8-naphthalimide group, [Ru(phen)2(pnip)]2 + (Ru1; phen = 1,10-phenanthroline, pnip = 2-[N-(p-phenyl)-1,8-napthalimide]imidazo[4',5'-f][1,10]phenanthroline) and [Ru(bpy)2(pnip)]2 + (Ru2; bpy = 2,2′-bipyridine), have been synthesized and characterized. The interactions of Ru1 and Ru2 with the triplex RNA poly(U)?poly(A)?poly(U) (where ? denotes the Watson-Crick base pairing and? denotes the Hoogsteen base pairing) were studied by various biophysical. Electronic spectra established that the binding affinity for Ru1 was greater than that for Ru2. Fluorescence and viscosity studies gave convincing evidence for a true intercalative binding of both complexes with the RNA triplex. UV melting studies confirmed that the two complexes could stabilize the triplex, whereas the effects of the two complexes on the stability of the Hoogsteen base-paired strand ploy(U) and the Watson-Crick base-paired duplex poly(U)?poly(A) of the triplex were different. In the case of Ru1, the increase of the thermal stability of the Hoogsteen base-paired strand was stronger than that of the Watson-Crick base-paired duplex. However, an opposite effect was observed in the case of Ru2. Circular dichroic studies suggested that the RNA triplex undergoes a conformational transition in the presence of Ru1, whereas the helicity of the RNA triplex still remains A-type in the presence of Ru2. The main results obtained here further advance our knowledge on the interaction of RNA triple-stranded structures with metal complexes, particularly ruthenium(II) complexes.
One Scaffold, Many Possibilities – Copper(I)-Catalyzed Azide–Alkyne Cycloadditions, Strain-Promoted Azide–Alkyne Cycloadditions, and Maleimide–Thiol Coupling of Ruthenium(II) Polypyridyl Complexes
Stumper, Anne,L?mmle, Martin,Mengele, Alexander K.,Sorsche, Dieter,Rau, Sven
, p. 586 - 596 (2018)
The applicability of RuII polypyridyl complexes with appropriate functionalities as substrates for biorthogonal coupling reactions is investigated. In detail, copper(I)-catalyzed azide–alkyne cycloadditions (CuAAC), strain-promoted azide–alkyne
Diatom-like silica–protein nanocomposites for sustained drug delivery of ruthenium polypyridyl complexes
Shi, Hongdong,Lou, Jingxue,Lin, Simin,Wang, Yi,Hu, Yatao,Zhang, Pingyu,Liu, Yangzhong,Zhang, Qianling
, (2021)
Inspired by the unique glass cell wall of diatom, we design a new nanostructure of human serum albumin nanoparticle (HSANP) coated with silica (HSA/SiO2), which consists of a core–satellite assembly of small silica nanoparticles on a single HSA
Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications
Chakrabortty, Sabyasachi,Agrawalla, Bikram Keshari,Stumper, Anne,Vegi, Naidu M,Fischer, Stephan,Reichardt, Christian,K?gler, Michael,Dietzek, Benjamin,Feuring-Buske, Michaela,Buske, Christian,Rau, Sven,Weil, Tanja
, p. 2512 - 2519 (2017)
Organelle-targeted photosensitization represents a promising approach in photodynamic therapy where the design of the active photosensitizer (PS) is very crucial. In this work, we developed a macromolecular PS with multiple copies of mitochondria-targeting groups and ruthenium complexes that displays highest phototoxicity toward several cancerous cell lines. In particular, enhanced anticancer activity was demonstrated in acute myeloid leukemia cell lines, where significant impairment of proliferation and clonogenicity occurs. Finally, attractive two-photon absorbing properties further underlined the great significance of this PS for mitochondria targeted PDT applications in deep tissue cancer therapy.
Metal iridium (III) complex as well as preparation method and application thereof
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Paragraph 0034; 0053; 0058, (2021/10/20)
The invention discloses a metal iridium (III) complex and a preparation method and application thereof, and belongs to the technical field of medicines. The metal iridium (III) complex of the present invention comprises a monovalent cation and a monovalen
