121731-21-3Relevant articles and documents
Orally Active Aldose Reductase Inhibitors Derived from Bioisosteric Substitutions on Tolrestat
Wrobel, Jay,Millen, Jane,Sredy, Janet,Dietrich, Arlene,Kelly, Joseph M.,et al.
, p. 2493 - 2502 (2007/10/02)
A series of aldose reductase inhibitors was prepared in which structural modifications were made to three positions of the potent, orally active inhibitor tolrestat (1), namely, the 6-methoxy substituent, thioamide sulfur, and the N-methyl moiety.These co