1217332-48-3Relevant academic research and scientific papers
Solid-phase synthesis of peptide-viologen conjugates
Reczek, Joseph J.,Rebolini, Elisa,Urbach, Adam R.
experimental part, p. 2111 - 2114 (2010/06/12)
Chemical Equation Presented This paper presents a robust method for the conjugation of viologens to peptides using an amide coupling strategy that is compatible with standard Fmoc solid-phase peptide synthesis. Methodology is presented for monitoring the milligram scale process quantitatively by UV spectroscopy. This chemistry enables the synthesis of a broad range of asymmetric viologens in high yield, at room temperature and is compatible with a wide range of functional groups, including amine, guanidinyl, thiol, carboxylic acid, phenol, and indole.
