1217341-91-7Relevant academic research and scientific papers
Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3
Dou, Dengfeng,He, Guijia,Li, Yi,Lai, Zhong,Wei, Liuqing,Alliston, Kevin R.,Lushington, Gerald H.,Eichhorn, David M.,Groutas, William C.
experimental part, p. 1093 - 1102 (2010/04/24)
The S′ subsites of human neutrophil proteinase 3 (Pr 3) were probed by constructing diverse libraries of compounds based on the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide using combinational and click chemistry methods. The multiple points of diversity embodied in the heterocyclic scaffold render it well-suited to the exploration of the S′ subsites of Pr 3. Molecular modeling studies suggest that further exploration of the S′ subsites of Pr 3 using the aforementioned heterocyclic scaffold may lead to the identification of highly selective, reversible competitive inhibitors of Pr 3.
