121735-41-9Relevant academic research and scientific papers
Chiral Phosphoric Acid-Catalyzed Kinetic Resolution via Amide Bond Formation
Shimoda, Yasushi,Yamamoto, Hisashi
, p. 6855 - 6858 (2017)
We describe the kinetic resolution of a readily available 2-pyridyl ester via an amide bond formation catalyzed by a chiral Br?nsted acid. A chiral phosphoric acid bearing a 2,4,6-trimethyl-3,5-dinitrophenyl group at the 3,3′-position enabled this transformation with high selectivities. We also found that the addition of Lewis acid increased both the reactivity and selectivity in the substrate with a methoxy group.
