1217357-16-8Relevant academic research and scientific papers
A Synthetic and Computational Investigation into the Direct Synthesis of α -Hydroxymethylated Enones from β-keto Phosphonates
Ryan, Sarah J.,Thompson, Christopher D.,Lupton, David W.
experimental part, p. 720 - 727 (2010/02/16)
The synthesis of a range of -hydroxymethylated enones has been achieved using the Villiras modification of the HornerWadsworthEmmons (HWE) reaction. Scope, limitations, and mechanistic aspects of this reaction were investigated using a combination of synthetic and computational studies. These investigations support a SchlosserCorey type reaction mechanism that is balanced between two pathways with the outcome influenced by the steric environment of the substrate. CSIRO 2009.
