1217364-23-2Relevant academic research and scientific papers
Synthesis and antimicrobial evaluation of halogen-containing arylidene thiazolo triazinediones
Karthikeyan, Mari Sithambaram,Mahalinga, Manjathuru,Karegoundar, Prakash,Poojary, Boja,Holla, Bantwal Shivarama
experimental part, p. 3231 - 3240 (2010/05/02)
A series of 7-substituted arylidene-1,3-thiazolo[2,3-c]-1,2,4-triazine-4,6- diones were synthesized in an one-pot multicomponent reaction of 6-arylmethyl-3-mercapto-1,2,4-triazin-5-ones with substituted benzaldehydes and monochloroacetic acid in the presence of acetic anhydride, acetic acid, and sodium acetate. The structures of the new compounds were supported by IR, 1H NMR, MS, and analytical data. All the new compounds were tested for their antibacterial and antifungal activity. Arylidene thiazolo triazinediones with 1,3-benzodioxolo substituent at seventh and p-chlorophenyl or 2,4-dichlorophenyl substituents at third displayed good antibacterial and antifungal activity. And also compound bearing 2,3,5-trimethoxyphenyl substituent at seventh and 2,4-dichlorophenyl substituent at third displayed good activity.
