12174-11-7

Basic information

• Product Name: ATTAPULGITE
• Synonyms: attagel50;Attapulgitee;attasorb;min-u-gel200;min-u-gel400;min-u-gelfg;palygorscite;palygorskit
• CAS NO: 12174-11-7
• Molecular Formula: 2Al.3Mg.6O3Si
• Molecular Weight: 583.377
• EINECS: 215-478-8
• Mol File: 12174-11-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 2.2 g/cm3
• Stability: Stable.
• CAS DataBase Reference: ATTAPULGITE(CAS DataBase Reference)
• NIST Chemistry Reference: ATTAPULGITE(12174-11-7)
• EPA Substance Registry System: ATTAPULGITE(12174-11-7)

Safety Data

• Hazardous Substances Data: 12174-11-7(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 12174-11-7 differently. You can refer to the following data:
1. solid
2. Attapulgite occurs as a light cream colored, very fine powder. Particle size ranges depend on the grade and manufacturer.

Uses

Different sources of media describe the Uses of 12174-11-7 differently. You can refer to the following data:
1. Excipient.
2. Worldwide attapulgite production in 1983 was estimated at about 1.1 million tons, of which 84% came from the United States. The primary use of attapulgite is as an animal waste absorbent (cat litter). Other important uses of attapulgite in the United States are as a component of drilling muds, as oil and grease absorbents, and in fertilizer and pesticide formulations.

Definition

A hydrated aluminum-magnesium silicate, the chief ingredient of fuller’s earth.

Production Methods

Attapulgite occurs naturally as the mineral palygorskite.

Hazard

Possible carcinogen.

Pharmaceutical Applications

Attapulgite is widely used as an adsorbent in solid dosage forms. Colloidal clays (such as attapulgite) absorb considerable amounts of water to form gels and in concentrations of 2–5% w/v usually form oil-in-water emulsions. Activated attapulgite, which is attapulgite that has been carefully heated to increase its absorptive capacity, is used therapeutically as an adjunct in the management of diarrhea.

Safety Profile

Suspected carcinogen with experimental neoplastigenic and tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Attapulgite is widely used in pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material. It is not absorbed following oral administration. In oral preparations, activated attapulgite up to 9 g is used in daily divided doses as an adjunct in the management of diarrhea.

storage

Attapulgite can adsorb water. It should be stored in an airtight container in a cool, dry, location.

Incompatibilities

Attapulgite may decrease the bioavailability of some drugs such as loperamide and riboflavin. Oxidation of hydrocortisone is increased in the presence of attapulgite.

Regulatory Status

Included in nonparenteral medicines licensed in a number of countries worldwide including the UK and USA.

InChI:InChI=1/Al.Mg.O3Si/c;;1-4(2)3/q+3;+2;-2

Related news

Capillary zone electrophoresis-tandem mass spectrometry for top-down proteomics using ATTAPULGITE (cas 12174-11-7) nanoparticles functionalized separation capillaries08/07/2019

Attapulgite nanoparticles have good chemical properties and can be modified easily for broad applications. In this work, for the first time, attapulgite nanoparticles were employed to modify the inner wall of separation capillaries for capillary zone electrophoresis-tandem mass spectrometry (CZE...detailed

Nanocomposite based on poly(acrylic acid) / ATTAPULGITE (cas 12174-11-7) towards flame retardant of cotton fabrics08/06/2019

The flammability of cotton fabric was improved by treated with the composite containing attapulgite(ATP). To achieve this aim, the poly(acrylic acid)/attapulgite nanocomposite (PAA/ATP) was successfully synthesized by the free radical polymerization of acrylic acid and the 3-methacryloxypropyltr...detailed

ATTAPULGITE (cas 12174-11-7) nanofibers and graphene oxide composite membrane for high-performance molecular separation08/03/2019

Graphene oxide (GO) based membranes are widely adopted in molecular separation based on size exclusion effect by stacked GO sheets. Both high flux and efficient rejection of GO-based membranes for long-term operation are highly expected for practical applications. Here, an attapulgite (ATP) nano...detailed

The preparation of bifunctional electrospun air filtration membranes by introducing ATTAPULGITE (cas 12174-11-7) for the efficient capturing of ultrafine PMs and hazardous heavy metal ions08/02/2019

The comprehensive sources of particulate matter (PM) require air purification materials to possess both high filtration efficiencies and low air resistances in an effort to provide healthcare. However, the assembly of multiple-layered filters with different functions leads to high pressure drop ...detailed

Hydroxyl-promoter on hydrated Ni-(Mg, Si) ATTAPULGITE (cas 12174-11-7) with high metal sintering resistance for biomass derived gas reforming08/01/2019

As hydrated magnesium-aluminum-silicate crystals, attapulgite and HNO3/NaOH pretreated attapulgite were used as support to prepare nickel-based catalysts via ultrasonic-assisted impregnation method. The as-prepared catalysts were employed in the biomass derived gas (especially CO2 and CH4) refor...detailed

Effect of ATTAPULGITE (cas 12174-11-7) colloids on uranium migration in quartz column07/31/2019

Clay minerals are widely used as backfill and buffer materials, and it is known that clay colloids derived from an engineered barrier system may affect the migration behaviors of radionuclides. Based on a study of the stability of attapulgite colloids and the sorption behavior of uranium on atta...detailed