121740-84-9

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 21040-45-9 Cinnamyl acetate 
• 14371-10-9 (E)-3-phenylpropenal 
• 548765-13-5 (E)‐2,2‐dimethyl‐5‐(3‐phenylallylidene)‐1,3‐dioxane‐4,6‐dione 
• 106625-69-8 ethyl (E)-3-phenyl-2-propenyl carbonate 

Downstream Products

• 22768-07-6 (E)-ethyl 5-phenylpent-4-enoate 
• 1619998-85-4 (E)-methyl 2-methylene-5-phenylpent-4-enoate 
• 1308888-04-1 (S,E)-5-(4-methoxyphenyl)-3-(nitromethyl)pent-4-enal 
• 1308888-03-0 (S,E)-3-(nitromethyl)-5-phenylpent-4-enal 
• 824431-60-9 2,2-Dimethyl-5-((E)-5-phenyl-pent-4-enyl)-5-[(E)-5-(4-trifluoromethyl-phenyl)-pent-4-enyl]-[1,3]dioxane-4,6-dione 
• 824431-62-1 2,2-Dimethyl-5-[(E)-5-(4-nitro-phenyl)-pent-4-enyl]-5-((E)-5-phenyl-pent-4-enyl)-[1,3]dioxane-4,6-dione 
• 824431-57-4 5-[(E)-5-(4-Chloro-phenyl)-pent-4-enyl]-2,2-dimethyl-5-((E)-5-phenyl-pent-4-enyl)-[1,3]dioxane-4,6-dione 
• 824431-51-8 5-[(E)-5-(4-Methoxy-phenyl)-pent-4-enyl]-2,2-dimethyl-5-((E)-5-phenyl-pent-4-enyl)-[1,3]dioxane-4,6-dione 
• 824431-54-1 2,2-Dimethyl-5-((E)-5-phenyl-pent-4-enyl)-5-((E)-5-p-tolyl-pent-4-enyl)-[1,3]dioxane-4,6-dione 

Relevant academic research and scientific papers

A novel and green protocol for two-carbon homologation: A direct amino acid/K2CO3-catalyzed four-component reaction of aldehydes, active methylenes, Hantzsch esters and alkyl halides

A novel and green approach for the two-carbon homologation of aldehydes using amino acid catalysis has been developed and further extended to the generation of pharmaceutically active cyano-esters via four-component reactions in one-pot.

Borohydride reduction of substituted isopropylidene methylenemalonates

Knoevenagel-type products derived from Meldrum's Acid are readily reduced by sodium borohydride to give monosubstituted isopropylidene malonates in high yield.

Oxidative and enantioselective cross-coupling of aldehydes and nitromethane catalyzed by diphenylprolinol silyl ether

Synthetically important β-substituted γ-nitro aldehydes have been synthesized with excellent enantioselectivity by the cross-coupling reaction of β-aryl substituted aldehydes or Y γ-unsaturated aldehydes and nitromethane using 2,3-dichloro-5,6-dicyanoquinone (DDQ) and diphenylprolinol silyl ether as an oxidant and catalyst, respectively (see scheme; TMS=trimethylsilyl).

Lewis base-promoted hydrosilylation of cyclic malonates: Synthesis of β-substituted aldehydes and γ-substituted amines

The Lewis base-promoted hydrosilylation of cyclic malonates provides a convenient synthesis of β-substituted aldehydes. No over-reduction to the primary alcohol is observed as the aldehyde functionality is protected until a subsequent hydrolysis step. The

Palladium(0)-Catalyzed Substitution of Allylic Substrates in an Aqueous-Organic Medium

A palladium(0)-water soluble catalyst prepared in situ from palladium acetate and the sulfonated triphenyl phosphine P(C6H4-m-SO3Na)3 (or tppts) is an efficient catalyst for allylic substitution with various carbon and heteronucleophiles in an aqueous-organic medium, allowing a very easy separation of the product(s) and the recycling of the catalyst.

PALLADIUM CATALYZED C-ALLYLATION OF HIGHLY ACIDIC CARBO AND HETEROCYCLIC β-DICARBONYL COMPOUNDS

Highly acidic carbo and heterocyclic β-dicarbonyl compounds such as barbituric acid, 3,5-dimethyl-2H-1,2,6-thiadiazine 1,1-dioxide, cyclohexane-1,3-dione, tetronic acids, Meldrum acid and 1,2-diphenylpyrazolidine-3,5-dione are efficiently C-allylated with primary and secondary allylating agents under palladium catalysis.