1217433-08-3Relevant academic research and scientific papers
Synthesis and antistaphylococcal activity of N-substituted-1H- benzimidazole-sulphonamides
Pueskuellue, M. Orhan,Yildiz, Sulhiye,Goeker, Hakan
experimental part, p. 31 - 39 (2010/06/19)
A series of N-substituted-1H-benzimidazole-5(6)-sulfonamides and 3-(5,6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzensulfonamides were synthesized and evaluated for antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Certain compounds inhibit bacterial growth with low MIC (μg/mL) values. The most active compounds 30, 31, and 32 have the lowest MIC values with 0.39 to 0.19 μg/mL. Among the compounds having sulfonamido moities, 16, 23, and 24 exhibited the strongest antibacterial activity with 1.56 μg/mL MIC values.
