1217438-45-3Relevant academic research and scientific papers
Palladium-catalyzed amination of aromatic C-H bonds with oxime esters
Tan, Yichen,Hartwig, John F.
supporting information; experimental part, p. 3676 - 3677 (2010/05/15)
"Chemical equation presented" We report a conceptually new approach to the direct amination of aromatic C-H bonds. In this process, an oxime ester function reacts with an aromatic C-H bond under redox-neutral conditions to form, in the case studied, an indole product. These reactions occur with relatively low catalyst loading (1 mol %) by a mechanism that appears to involve an unusual initial oxidative addition of an N-O bond to a Pd(0) species. The Pd(II) complex from oxidative addition of the N-X bond has been isolated for the first time, and evidence for the intermediacy of such oxidative addition products in the catalytic reaction has been gained.
