1217447-83-0

Basic information

• Product Name: C₃₈H₃₃F₂O₁₄P
• CAS NO: 1217447-83-0
• Molecular Weight: 782.642
• Mol File: 1217447-83-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₈H₃₃F₂O₁₄P(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₈H₃₃F₂O₁₄P(1217447-83-0)
• EPA Substance Registry System: C₃₈H₃₃F₂O₁₄P(1217447-83-0)

Safety Data

• Hazardous Substances Data: 1217447-83-0(Hazardous Substances Data)

Upstream product

• 97614-44-3 2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide 

Relevant articles and documents

Stereoselective synthesis of 2-deoxy-2-fluoroarabinofuranosyl-α-1- phosphate and its application to the synthesis of 2′-Deoxy-2′- fluoroarabinofuranosyl purine nucleosides by a chemo-enzymatic method

Stereoselective introduction of a phosphate moiety into 2-deoxy-2-fluoroarabinofuranose derivatives at the anomeric position was investigated by two methods. One involved a stereoselective hydrolysis of 1-bromo-derivative, and the consecutive phosphorylation of 2-deoxy-2-fluoro- α-D-arabinofuranose via a phosphoramidite derivative. The other method involved stereoselective α-phosphorylation of the 1-bromo-derivative at the 1-position. The resulting α-1-phosphate was utilized to prepare 2′-deoxy-2′-fluoroarabinofuranosyl purine nucleosides by an enzymatic glycosylation reaction. This chemo-enzymatic method will be applicable to the synthesis of some 2′F-araNs, and three important 2′F-araNs were actually obtained in 30-40% yields from 1,3,5-tri-O-benzoyl-2-deoxy-2- fluoro-α-D-arabinose with high purity.