121746-07-4Relevant academic research and scientific papers
A Facile Synthesis of 2-Alkylthio-4-amino-thienopyrimidines
Leistner, Siegfried,Guetschow, Michael,Wagner, Guenther
, p. 227 - 230 (1989)
The reaction of 2-benzoylthioureidothiophene-3-carbonitriles D/8,9 with diluted NaOH yields 4-amino-thienopyrimidin-2(1H)-thiones E/10,11.Compounds D react in alkaline solution with various alkyl halides in one step to give 2-alkylthio-4-amino-thie
2-(Benzoylimino)thiazolidin-4-ones: Formation by an alternative ring closure and analysis of rotational barriers
Hcker, Hans-Georg,Elsinghorst, Paul W.,Michels, Susanne,Daniels, Joerg,Schnakenburg, Gregor,Guetschow, Michael
experimental part, p. 1195 - 1203 (2009/12/04)
The reactions of N-benzoyl-N'-(o-cyanoaryl)thioureas with ethyl bromoacetate under alkaline conditions led to the formation of either fused 2-(alkylsulfanyl)-4-aminopyrimidines or 2-(benzoylimino)-3-(o-cyanoaryl) thiazolidin-4-ones. The accurate applicati
Analogs of a 4-aminothieno[2,3-d]pyrimidine lead (QB13) as modulators of P-glycoprotein substrate specificity
Haecker, Hans-Georg,Haye, Antje de la,Sterz, Katja,Schnakenburg, Gregor,Wiese, Michael,Guetschow, Michael
supporting information; experimental part, p. 6102 - 6105 (2010/06/19)
P-glycoprotein (P-gp) is an important factor in the development of multidrug resistance (MDR) in cancer cells. In literature reports, a thieno[2,3-d]pyrimidine (QB13) was described as P-gp modulator and opposed effects on the cell accumulation of distinct
MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH
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Page/Page column 56, (2009/01/20)
The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.
