121746-14-3Relevant academic research and scientific papers
Analogs of a 4-aminothieno[2,3-d]pyrimidine lead (QB13) as modulators of P-glycoprotein substrate specificity
Haecker, Hans-Georg,Haye, Antje de la,Sterz, Katja,Schnakenburg, Gregor,Wiese, Michael,Guetschow, Michael
supporting information; experimental part, p. 6102 - 6105 (2010/06/19)
P-glycoprotein (P-gp) is an important factor in the development of multidrug resistance (MDR) in cancer cells. In literature reports, a thieno[2,3-d]pyrimidine (QB13) was described as P-gp modulator and opposed effects on the cell accumulation of distinct
Reaction of Nitriles under Acidic Conditions. Part VI. Synthesis of Condensed 4-Chloro- and 4-Aminopyrimidines from ortho-Aminonitriles
Shishoo, C. J.,Devani, M. B.,Bhadti, V. S,Jain, K. S.,Ananthan, S.
, p. 119 - 126 (2007/10/02)
Condensation of a nitrile with benzene, furan and thiophene ortho-aminonitriles in the presence of dry hydrogen chloride yields condensed 4-chloropyrimidines, condensed 4-aminopyrimidines or a mixture of the two condensed pyrimidines in varying proportions depending upon the nature of the nitrile and the substrate, ortho-aminonitrile.
A Facile Synthesis of 2-Alkylthio-4-amino-thienopyrimidines
Leistner, Siegfried,Guetschow, Michael,Wagner, Guenther
, p. 227 - 230 (2007/10/02)
The reaction of 2-benzoylthioureidothiophene-3-carbonitriles D/8,9 with diluted NaOH yields 4-amino-thienopyrimidin-2(1H)-thiones E/10,11.Compounds D react in alkaline solution with various alkyl halides in one step to give 2-alkylthio-4-amino-thie
