1217630-38-0Relevant articles and documents
Efficient preparation of (R)-2-(2,5-difluorophenyl)pyrrolidine via a recycle process of resolution
Lv, Xunlei,Chen, Liang,Pan, Jing,Meng, Xue,Bi, Siju,Liu, Weiyuan,Zhou, Ting,Lin, Kuaile,Ye, Deyong,Zhou, Weicheng
, p. 931 - 937 (2021/10/19)
An efficient preparation of (R)-2-(2,5-difluorophenyl)pyrrolidine ((R)-1) from the racemate based on a recycle process of resolution/racemization was described. In the process, the desired (R)-1 was obtained by resolution with D-malic acid in 95% EtOH. Me
FIVE-AND-SIX-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS PROTEIN RECEPTOR KINASE INHIBITOR
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Paragraph 0060; 0065-0066, (2021/12/18)
A class of five-membered fused with six-membered heterocyclic compounds represented by formula I and a pharmaceutical composition, preparation, and an application thereof are disclosed. These compounds have TRK kinase inhibitory activity and can treat diseases related to TRK dysfunction.
SIX-MEMBERED AND SIX-MEMBERED HETEROCYCLIC COMPOUND AND USES THEREOF SERVING AS PROTEIN RECEPTOR KINASE INHIBITOR
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Paragraph 0078; 0083-0084, (2021/09/24)
Provided are a preparation and applications of a six-membered fused with six-membered heterocyclic compound, specifically, provided in the present invention is a compound as represented by formula I as follows, where the definitions of the groups are as described in the description. The compound has TRK kinase inhibiting activity and can serve as a pharmaceutical composition for treating TRK dysfunction-related diseases.